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|Abstract:||The invention provides unit dosage forms, kits, and methods useful for treating viral infections.|
|Inventor(s):||Babu; Yarlagadda Sudhakara (Birmingham, AL), Chand; Pooran (Birmingham, AL), Bantia; Shanta (Birmingham, AL), Arnold; Shane (Hoover, AL), Kilpatrick; John Michael (Helena, AL)|
|Assignee:||BioCryst Pharmaceuticals, Inc. (Birmingham, AL)|
1. A method for treating a viral infection in a human in need thereof comprising administering in a single intravenous administration an effective anti-viral amount of a
compound of formula I: ##STR00026## or a pharmaceutically acceptable salt thereof, to the human, wherein the viral infection is an H3N2, H1N1, H5N1, avian, or seasonal influenza infection.
2. The method of claim 1, wherein the compound of formula I is a compound of formula Ia: ##STR00027## or a pharmaceutically acceptable salt thereof.
3. The method of claim 1, wherein the effective anti-viral amount is up to about 800 mg.
4. The method of claim 3, wherein the effective anti-viral amount is up to about 600 mg.
5. The method of claim 4, wherein the effective anti-viral amount is up to about 300 mg.
6. The method of claim 1, wherein the effective anti-viral amount is about 600 mg.
7. The method of claim 1, wherein the effective anti-viral amount is about 300 mg.
8. The method of claim 1, wherein the plasma concentration of the compound is higher than the IC.sub.50 of the virus causing the viral infection 12 hours following administration of the compound.
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