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|Title:||Treatment of solid tumors with rapamycin derivatives|
|Abstract:||Rapamycin derivatives have interesting effects in the treatment of solid tumours, optionally in combination with a chemotherapeutic agent.|
|Inventor(s):||Lane; Heidi (Basel, CH), O'Reilly; Terence (Basel, CH), Wood; Jeanette Marjorie (Biel-Benken, CH)|
|Assignee:||Novartis Pharmaceuticals Corporation (East Hanover, NJ)|
1. A method for inhibiting growth of non-malignant solid tumors of the brain in a subject, said method consisting of administering to said subject a therapeutically
effective amount of a compound of formula I ##STR00002## wherein R.sub.1 is CH.sub.3, R.sub.2 is --CH.sub.2--CH.sub.2--OH, and X is .dbd.O.
2. The method of claim 1 wherein the compound of formula I is administered at a daily dose range of from about 0.1 to 25 mg, as a single dose or in divided doses.
3. The method of claim 1 wherein the compound of formula I is administered in a unit dosage form of from about 0.05 to 12.5 mg.
4. The method of claim 1 wherein the compound of formula I is administered in a unit dosage form of from about 0.25 to 10 mg.
5. The method of claim 1 wherein the compound of formula I is administered in a unit dosage form of 10 mg.
6. The method of claim 1 wherein the compound of formula I is administered orally.
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