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|Abstract:||Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.|
|Inventor(s):||McGlynn; Paul (Marlborough, MA), Bakale; Roger (Shrewsbury, MA), Sturge; Craig (Falmouth, CA)|
1. An aerosol formulation comprising (a) crystalline levalbuterol L-tartrate, (b) ethanol, and (c) a propellant, wherein particles comprising crystalline levalbuterol
L-tartrate from the formulation have a mass median aerodynamic diameter from 1 to 10 microns as measured by an Andersen Cascade Impactor, wherein the crystalline levalbuterol L-tartrate is in the form of needle-like particles, wherein the crystalline
levalbuterol L-tartrate is in the form of needle-like particles.
2. The aerosol formulation of claim 1, wherein the particles comprising crystalline levalbuterol L-tartrate have a mass median aerodynamic diameter of from 1 to 5 microns.
3. The aerosol formulation of claim 1, wherein ethanol is present in an amount up to 10% by weight of the aerosol formulation.
4. The aerosol formulation of claim 3, wherein ethanol is present in an amount from 2% to 6% by weight of the aerosol formulation.
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