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Claims for Patent: 8,748,425

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Claims for Patent: 8,748,425

Title:Combination of brimonidine and timolol for topical ophthalmic use
Abstract: Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans.
Inventor(s): Chang; Chin-Ming (Tustin, CA), Beck; Gary J. (Fullerton, CA), Pratt; Cynthia C. (Mission Viejo, CA), Batoosingh; Amy L. (Mission Viejo, CA)
Assignee: Allergan Sales, LLC (Irvine, CA)
Application Number:13/957,287
Patent Claims: 1. A method of treating a patient with glaucoma or ocular hypertension comprising administering twice daily to an affected eye a single composition comprising 0.2% w/v brimonidine tartrate and 0.5% w/v timolol free base, wherein said method reduces the incidence of one or more adverse events, as compared to the administration of 0.2% w/v brimonidine tartrate monotherapy three times per day wherein the adverse event is selected from the group consisting of conjunctival hyperemia, oral dryness, eye pruritus, allergic conjunctivitis, foreign body sensation, conjunctival folliculosis, and somnolence.

2. The method of claim 1, wherein the adverse event is conjunctival hyperemia.

3. The method of claim 1, wherein the adverse event is oral dryness.

4. The method of claim 1, wherein the adverse event is eye pruritus.

5. The method of claim 1, wherein the adverse event is allergic conjunctivitis.

6. The method of claim 1, wherein the adverse event is foreign body sensation.

7. The method of claim 1, wherein the adverse event is conjunctival folliculosis.

8. The method of claim 1, wherein the adverse event is somnolence.
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