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Last Updated: April 26, 2024

Claims for Patent: 8,735,393

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Summary for Patent: 8,735,393

Title:	Anhydrous topical skin preparations
Abstract:	The present invention provides anhydrous compositions for topical delivery of a medicament comprising (A) a penetration enhancer/solvent selected from the group consisting of alcohol, propylene glycol, or a combination thereof; (B) a humectant/solvent selected from the group consisting of polyethylene glycol, glycerin, sorbitol, xylitol, or any combination of any of the foregoing; and (C) an anhydrous vehicle. In an alternate embodiment, the present invention provides anhydrous compositions for topical delivery of a medicament which comprise (A) a penetration enhancer/solvent selected from the group consisting of alcohol, propylene glycol, or a combination thereof; (B) a humectant/solvent selected from the group consisting of polyethylene glycol, glycerin, sorbitol, xylitol or any combination of any of the foregoing; (C) an anhydrous vehicle; and (D) a medicament. Also provided are methods for topically delivering a medicament to an animal.
Inventor(s):	Burnett; Katherine M. (Basking Ridge, NJ), Kurtz; Ellen S. (Ringoes, NJ)
Assignee:	Johnson & Johnson Consumer Companies, Inc. (Skillman, NJ)
Application Number:	13/560,761
Patent Claims:	1. An anhydrous composition formulated for topical delivery consisting of: (a) about 20 percent by weight of propylene glycol, (b) about 20 percent by weight of polyethylene glycol, (c) about 20 percent by weight of glycerin, (d) about 34 percent by weight of ethanol, (e) about 2 percent by weight of ketoconazole, (f) PPG-15 stearyl ether, (g) hydroxypropyl cellulose, (h) ascorbic acid, (i) butylated hydroxytoluene, (j) citric acid, and (k) at least one colorant, wherein the composition is formulated as an anhydrous gel. 2. The composition of claim 1 wherein the ketoconazole is solubilized. 3. An anhydrous composition formulated for topical delivery consisting of: (a) about 20 percent by weight of propylene glycol, (b) about 20 percent by weight of polyethylene glycol, (c) about 20 percent by weight of glycerin, (d) about 34 percent by weight of ethanol, (e) about 2 percent by weight ketoconazole, (f) PPG-15 stearyl ether, (g) hydroxypropyl cellulose, (h) ascorbic acid, (i) butylated hydroxytoluene, (j) citric acid, and (k) at least one member selected from the group consisting of a colorant, fragrance, UV stabilizer and sunscreen, wherein the composition is formulated as an anhydrous gel. 4. An anhydrous composition formulated for topical delivery consisting of: (a) about 20 percent by weight of propylene glycol, (b) about 20 percent by weight of polyethylene glycol, (c) about 20 percent by weight of glycerin, (d) about 34 percent by weight of ethanol, (e) about 2 percent by weight ketoconazole, (f) PPG-15 stearyl ether, (g) hydroxypropyl cellulose, (h) ascorbic acid, (i) butylated hydroxytoluene, and (j) citric acid, wherein the composition is formulated as an anhydrous gel. 5. The composition of claim 3 wherein the ketoconazole is solubilized. 6. The composition of claim 4 wherein the ketoconazole is solubilized.

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