.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 8,734,845

« Back to Dashboard

Claims for Patent: 8,734,845

Title:Diketopiperazine microparticles with defined specific surface areas
Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m.sup.2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
Inventor(s): Grant; Marshall L. (Newtown, CT), Stowell; Grayson W. (Gaylordsville, CT), Menkin; Paul (Branford, CT)
Assignee: Mannkind Corporation (Valencia, CA)
Application Number:13/377,682
Patent Claims: 1. Diketopiperazine microparticles having a specific surface area of from about 35 m.sup.2/g to about 67 m.sup.2/g.

2. The diketopiperazine microparticles according to claim 1, wherein said microparticles comprise a drug or active agent.

3. The diketopiperazine microparticles according to claim 2, wherein said specific surface area is less than about 62 m.sup.2/g.

4. The diketopiperazine microparticles according to claim 3, wherein said drug or active agent is a peptide or protein.

5. The diketopiperazine microparticles according to claim 4, wherein said peptide is an endocrine hormone.

6. The diketopiperazine microparticles according to claim 5, wherein said endocrine hormone is insulin, parathyroid hormone, calcitonin, glucagon, glucagon-like peptide 1, oxyntomodulin, an analog or active fragment of said endocrine hormone.

7. The diketopiperazine microparticles according to claim 1, wherein said diketopiperazine is fumaryl diketopiperazine.

8. The diketopiperazine microparticles of claim 6 in a dry powder form.

9. The diketopiperazine microparticles of claim 6 wherein said endocrine hormone is insulin or an analog or active fragment thereof.

10. The diketopiperazine microparticles of claim 6 wherein said endocrine hormone is glucagon-like peptide 1 or an analog or active fragment thereof.

11. The diketopiperazine microparticles of claim 1 having a specific surface area of from about 45 m.sup.2/g to about 67 m.sup.2/g.

12. The diketopiperazine microparticles of claim 1 having a specific surface area of from about 35 m.sup.2/g to about 56 m.sup.2/g.

13. The diketopiperazine microparticles of claim 1 having a specific surface area of from about 45 m.sup.2/g to about 56 m.sup.2/g.

14. The diketopiperazine microparticles of claim 9 wherein said endocrine hormone is insulin.

15. The diketopiperazine microparticles of claim 14 wherein the microparticles are about 10-15% insulin by weight.

16. The diketopiperazine microparticles of claim 5, wherein said endocrine hormone is an exendin.

17. The diketopiperazine microparticles of claim 14 wherein the microparticles comprise 3-4 U/mg insulin.

18. The diketopiperazine microparticles of claim 15 wherein the microparticles are about 11% insulin.

19. The diketopiperazine microparticles of claim 2 wherein said drug or active agent comprises about 0.01% to about 20% of the weight of the microparticles.

20. A dry powder comprising the diketopiperazine microparticles of claim 19.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc