Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

US Army
Argus Health
Fish and Richardson
Cantor Fitzgerald

Generated: June 18, 2018

DrugPatentWatch Database Preview

Claims for Patent: 8,663,699

« Back to Dashboard

Summary for Patent: 8,663,699
Title:Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent
Abstract: An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.
Inventor(s): Chang; Yunik (Sonoma, CA), Dow; Gordon J. (Santa Rosa, CA)
Assignee: Dow Pharmaceutical Sciences, Inc. (Petaluma, CA)
Application Number:13/869,494
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,663,699
Patent Claims: 1. A method for treating acne comprising topically applying an effective amount of a stable pharmaceutically acceptable aqueous gel formulation comprising anti-acne active pharmaceutical ingredients consisting of 2.5% w/w benzoyl peroxide and 1.2% w/w clindamycin phosphate once daily to acne affected skin of a patient in need thereof, wherein the irritation potential of the once daily application is less than and the efficacy of the once daily application in terms of reduction of acne inflammatory and non-inflammatory lesions is similar to that obtained by twice daily application of a topic gel composition containing 5.0% benzoyl peroxide, 1% clindamycin, dicotyl sodium sulfosuccinate, and water.

2. The method of claim 1, wherein the benzoyl peroxide in the formulation is in suspension and has an average particle size of 2.5 to 30 microns.

3. The method of claim 2, wherein the aqueous formulation comprises a gelling agent selected from the group consisting of carbomer, hydroxyethyl cellulose, and hydroxypropyl cellulose gelling agents.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
Argus Health
Queensland Health
US Army

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.