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|Title:||Methods and compositions for increasing solubility of azole drug compounds that are poorly soluble in water|
|Abstract:||The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.|
|Inventor(s):||Yang; Meidong (Richmond, CA), Chen; Haigang (Petaluma, CA)|
|Assignee:||Dow Pharmaceutical Sciences, Inc. (Petaluma, CA)|
1. A method for treating a dermatologic or mucosal disorder that is responsive to treatment with an azole compound comprising applying to the skin or mucosa of an
individual suffering from said disorder a pharmaceutical formulation comprising water, metronidazole at a concentration between 1.25% and 1.5%, and at least two of a polyol, a polyol ether, and a low carbon organic alcohol.
2. The method of claim 1 wherein the formulation is applied one or more times daily for a duration sufficient to ameliorate the disorder.
3. The method of claim 1 wherein the disorder is infectious.
4. The method of claim 3 wherein, the infectious disorder is fungal.
5. The method of claim 1 wherein the individual is human.
6. The method of claim 1 wherein the low carbon organic alcohol is benzyl alcohol.
7. The method of claim 6 wherein the benzyl alcohol comprises about 1% w/w of the formulation.
8. The method of claim 7 wherein the benzyl alcohol comprises about 2% w/w of the formulation.
9. The method of claim 1 wherein the polyol is propylene glycol.
10. The method of claim 1 wherein the polyol ether is an ether of an alkylene glycol.
11. The method of claim 10 wherein the ether of the alkylene glycol is polyethylene glycol.
12. The method of claim 11 wherein the polyethylene glycol is polyethylene glycol 400 ("PEG 400").
13. The method of claim 1 wherein the water comprises about 55% or more w/w of the formulation.
14. The method of claim 1 wherein the formulation comprises each of a polyol, a polyol ether, and a low carbon organic alcohol.
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