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Last Updated: March 4, 2021

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Claims for Patent: 8,658,205

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Summary for Patent: 8,658,205
Title:Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
Abstract: The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.
Inventor(s): Hui; Poh K. (Wellesley Hills, MA), Bishop; John E. (Groton, MA), Madrigal, Jr.; Eleodoro S. (Westford, MA)
Assignee: Lantheus Medical Imaging, Inc. (North Billerica, MA)
Application Number:13/195,734
Patent Claims: 1. A composition comprising 1,2-dipalmitoyl-sn-glycero-3-phosphotidic acid, mono sodium salt (DPPA), 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), and N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine, mono sodium salt (MPEG5000-DPPE), present in a mole ratio of 10% to 82% to 8%, and in an amount of about 0.75 mg/mL; sodium chloride; glycerin, present in an amount of about 0.1 mL/mL; propylene glycol, present in an amount of about 0.1 mL/mL; water, and perfluoropropane.

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