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|Title:||Solid preparation comprising alogliptin and pioglitazone|
|Abstract:||A solid preparation containing compound (I), wherein the definition of compound (I) is as defined in the description, and pioglitazone, which is useful as a therapeutic drug for diabetes and the like and superior in the dissolution property, chemical stability and dissolution stability, is provided. A solid preparation containing the following first and second parts: (1) the first part containing compound (I) or a salt thereof and, as the first excipient, sugar or sugar alcohol; and (2) the second part containing pioglitazone or a salt thereof and, as the second excipient, sugar or sugar alcohol.|
|Inventor(s):||Nakamura; Kenji (Osaka, JP), Kiyoshima; Kenichiro (Osaka, JP), Nomura; Junya (Osaka, JP)|
|Assignee:||Takeda Pharmaceutical Company Limited (Osaka, JP)|
1. A multi-layered tablet comprising the following first and second layers: (1) the first layer comprising compressed granules comprising
2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-p- yrimidinyl]methyl]-benzonitrile or a salt thereof and, as a first excipient, sugar or sugar alcohol; and (2) the second layer comprising compressed granules comprising
pioglitazone or a salt thereof and, as a second excipient, lactose.
2. The multi-layer tablet of claim 1, wherein the first excipient sugar or sugar alcohol is lactose, sucrose, erythritol or mannitol.
3. The multi-layer tablet of claim 2, wherein the first excipient is mannitol.
4. The multi-layer tablet of claim 1, wherein the second layer comprises pioglitazone or a salt thereof, lactose and hydroxypropylcellulose.
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