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BioPharmaceutical Business Intelligence

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Serving leading biopharmaceutical companies globally:

Deloitte
US Department of Justice
Medtronic
McKinsey
Merck
Johnson and Johnson
Julphar
US Army
Dow
Teva

Generated: November 21, 2017

DrugPatentWatch Database Preview

Claims for Patent: 8,637,079

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Claims for Patent: 8,637,079

Title:Solid preparation comprising alogliptin and pioglitazone
Abstract: A solid preparation containing compound (I), wherein the definition of compound (I) is as defined in the description, and pioglitazone, which is useful as a therapeutic drug for diabetes and the like and superior in the dissolution property, chemical stability and dissolution stability, is provided. A solid preparation containing the following first and second parts: (1) the first part containing compound (I) or a salt thereof and, as the first excipient, sugar or sugar alcohol; and (2) the second part containing pioglitazone or a salt thereof and, as the second excipient, sugar or sugar alcohol.
Inventor(s): Nakamura; Kenji (Osaka, JP), Kiyoshima; Kenichiro (Osaka, JP), Nomura; Junya (Osaka, JP)
Assignee: Takeda Pharmaceutical Company Limited (Osaka, JP)
Application Number:12/449,255
Patent Claims: 1. A multi-layered tablet comprising the following first and second layers: (1) the first layer comprising compressed granules comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-p- yrimidinyl]methyl]-benzonitrile or a salt thereof and, as a first excipient, sugar or sugar alcohol; and (2) the second layer comprising compressed granules comprising pioglitazone or a salt thereof and, as a second excipient, lactose.

2. The multi-layer tablet of claim 1, wherein the first excipient sugar or sugar alcohol is lactose, sucrose, erythritol or mannitol.

3. The multi-layer tablet of claim 2, wherein the first excipient is mannitol.

4. The multi-layer tablet of claim 1, wherein the second layer comprises pioglitazone or a salt thereof, lactose and hydroxypropylcellulose.
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Serving leading biopharmaceutical companies globally:

McKesson
Healthtrust
Federal Trade Commission
Dow
Chinese Patent Office
Medtronic
QuintilesIMS
Covington
Moodys
Farmers Insurance

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