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Last Updated: December 12, 2025

Claims for Patent: 8,633,309

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Summary for Patent: 8,633,309

Title:	Nucleoside phosphoramidates
Abstract:	Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
Inventor(s):	Bruce Ross, Michael Joseph Sofia, Ganapati REDDY PAMULAPATI, Suguna Rachakonda, Hai-Ren Zhang, Byoung-Kwon Chun, Peiyuan Wang
Assignee:	Gilead Sciences Inc
Application Number:	US13/738,425
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,633,309
Patent Claims:	1. A compound represented by the formula (4): wherein P* represents a chiral phosphorus atom and wherein the compound is at least 97% of the SPstereoisomer represented by the formula (SP-4): and not more than 3% of the RPstereoisomer represented by the formula (RP-4): 2. The compound according to claim 1, wherein the compound is at least 98% of the SPstereoisomer represented by the formula (SP-4) and not more than 2% of the RPstereoisomer represented by the formula (RP-4). 3. The compound according to claim 1, wherein the compound is at least 99% of the SPstereoisomer represented by the formula (SP-4) and not more than 1% of the RPstereoisomer represented by the formula (RP-4). 4. A pharmaceutical composition comprising the compound according to claim 1 and a pharmaceutically acceptable medium. 5. A pharmaceutical composition comprising the compound according to claim 2 and a pharmaceutically acceptable medium. 6. A pharmaceutical composition comprising the compound according to claim 3 and a pharmaceutically acceptable medium. 7. A method of treating a hepatitis C virus infection in a human comprising administering to the human an effective amount of the compound according to claim 1. 8. The method according to claim 7 further comprising administering to the human another antiviral agent. 9. A method of treating a hepatitis C virus infection in a human comprising administering to the human an effective amount of the compound according to claim 2. 10. The method according to claim 9 further comprising administering to the human another antiviral agent. 11. A method of treating a hepatitis C virus infection in a human comprising administering to the human an effective amount of the compound according to claim 3. 12. The method according to claim 11 further comprising administering to the human another antiviral agent.

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