Claims for Patent: 8,609,862

Summary for Patent: 8,609,862

Title:	Use of an adrenal hormone-modifying agent
Abstract:	The present invention relates to a method of treating a disease or disorder characterised by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I): wherein n is 1 or 3; R is hydrogen or —C(O)N(Ra)(Rb) wherein Ra and Rb are independently —(C1-C4)alkyl, or —(C1-C4)alkyl-(C5-C7)aryl, wherein each of Ra and Rb is optionally substituted by —(C1-C4)alkoxy; R1, R2, and R3, are independently hydrogen, halogen, cyano or —(C6-C10) aryl, wherein said —(C6-C10)aryl is optionally substituted by halogen, with the proviso that no more than one of R1, R2, and R3 is hydrogen; and R4 and R5 are hydrogen; or a pharmaceutically acceptable salt thereof.
Inventor(s):	Qi-Ying Hu, Gary Michael Ksander, Erik Meredith, Lauren G. Monovich, Julien Papillon, Christoph Schumacher
Assignee:	Recordati SA
Application Number:	US13/521,548
Patent Claims:	1. A method of treating a disease or disorder characterized by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the disease or disorder is Cushing's syndrome, Cushing's disease or cachexia selected from cardiac cachexia, COPD-induced cachexia, cirrhosis-induced cachexia, tumor-induced cachexia, or viral (HIV)-induced cachexia, and wherein the treating a disease or disorder is partially or totally ameliorating the disease or disorder, partially or totally ameliorating at least one physical parameter of the disease or disorder, modulating the disease or disorder, or delaying the onset or development or progression of the disease or disorder. 2. The method according to claim 1 wherein said the compound of formula I is in the salt form of dihydrogen phosphate. 3. The method according to claim 1 wherein the disease or disorder is Cushing's syndrome. 4. The method according to claim 1 wherein the disease or disorder is Cushing's disease. 5. The method according to claim 1, wherein the disease or disorder is cachexia is selected from cardiac cachexia, COPD-induced cachexia, cirrhosis-induced cachexia, tumor-induced cachexia, or viral (HIV)-induced cachexia.