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Generated: December 15, 2017

DrugPatentWatch Database Preview

Claims for Patent: 8,609,709

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Claims for Patent: 8,609,709

Title:Compounds as opioid receptor modulators
Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). ##STR00001## The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
Inventor(s): Breslin; Henry J. (Lansdale, PA), Cai; Chaozhong (North Wales, PA), He; Wei (Audubon, PA), Kavash; Robert W. (Glenside, PA)
Assignee: Janssen Pharmaceutica, N. V. (Beerse, BE)
Application Number:13/690,041
Patent Claims: 1. A compound having the structure: ##STR00046## or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 having the structure: ##STR00047##

3. The compound of claim 2, having the structure: ##STR00048##

4. The compound of claim 2, having the structure: ##STR00049##

5. The compound of claim 2, having the structure: ##STR00050##

6. A pharmaceutically acceptable salt of the compound according to claim 1.

7. The compound of claim 6, wherein the salt is a hydrochloric, hydrobromic, hydriodic, perchloric, sulfuric, nitric, phosphoric, acetic, propionic, glycolic, lactic, succinic, maleic, fumaric, malic, tartaric, citric, benzoic, mandelic, methanesulfonic, hydroxyethanesulfonic, benzenesulfonic, oxalic, pamoic, 2-naphthalenesulfonic, p-toluenesulfonic, cyclohexanesulfamic, salicylic, saccharinic, or trifluoroacetic acid salt.

8. The compound of claim 6, wherein the salt is a benzathine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine, procaine, aluminum, calcium, lithium, magnesium, potassium, sodium, or zinc salt.
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McKesson
Daiichi Sankyo

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