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Claims for Patent: 8,580,796

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Claims for Patent: 8,580,796

Title:Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
Abstract: The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous Aripiprazole crystals is stored for an extended period.
Inventor(s): Bando; Takuji (Tokushima, JP), Aoki; Satoshi (Naruto, JP), Kawasaki; Junichi (Tokushima, JP), Ishigami; Makoto (Tokushima, JP), Taniguchi; Youichi (Tokushima, JP), Yabuuchi; Tsuyoshi (Tokushima, JP), Fujimoto; Kiyoshi (Naruto, JP), Nishioka; Yoshihiro (Tokushima, JP), Kobayashi; Noriyuki (Tokushima, JP), Fujimura; Tsutomu (Naruto, JP), Takahashi; Masanori (Tokushima, JP), Abe; Kaoru (Tokushima, JP), Nakagawa; Tomonori (Tokushima, JP), Shinhama; Koichi (Tokushima, JP), Utsumi; Naoto (Naruto, JP), Tominaga; Michiaki (Tokushima, JP), Ooi; Yoshihiro (Tokushima, JP), Yamada; Shohei (Tokushima, JP), Tomikawa; Kenji (Tokushima, JP)
Assignee: Otsuka Pharmaceutical Co., Ltd. (Tokyo, JP)
Application Number:13/350,117
Patent Claims: 1. Anhydrous Aripiprazole Crystals B having low hygroscopicity wherein said low hygroscopicity is defined as a moisture content of 0.40% or less when said Crystals are placed for 24 hours in a dessicator maintained at a temperature of 60.degree. C. and a humidity level of 100%.

2. Anhydrous Aripiprazole Crystals B having low hygroscopicity wherein said low hygroscopicity is defined as a moisture content of 0.10% or less when said Crystals are placed for 24 hours in a dessicator maintained at a temperature of 60.degree. C. and a humidity level of 100%.
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