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Claims for Patent: 8,562,564

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Claims for Patent: 8,562,564

Title:Prefilled syringe jet injector
Abstract: A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.
Inventor(s): Lesch, Jr.; Paul R. (Lino Lakes, MN)
Assignee: Antares Pharma, Inc. (Ewing, NJ)
Application Number:13/236,120
Patent Claims: 1. A jet injector, comprising: a syringe support configured for supporting a syringe by a radial flange thereof, which syringe comprises: a syringe body that includes: a syringe wall defining a container portion defining a fluid chamber containing a medicament, a flange extending radially from the syringe wall and shaped for grasping for injection by hand when the syringe is used independently, and a plunger movable within the fluid chamber to expel the medicament, and a needle disposed at the distal end of the syringe body, having an injection tip configured for piercing an insertion location, and defining a fluid pathway in fluid communication with the chamber for injecting the fluid expelled from the chamber into an injection site; an energy source configured for biasing the plunger with a force sufficient to produce an injecting pressure in the medicament in the chamber maintained between about 80 p.s.i. and 1000 p.s.i, during injection of the medicament to jet inject the medicament from the fluid chamber through the needle to the injection site; and a cushion associated with the syringe support and made of a sufficiently resilient material and configured to compensate for shape irregularities of the flange and absorb shock on the flange from the jet injection to protect the flange from breaking.

2. The jet injector of claim 1, wherein the flange extends from a proximal portion of the syringe wall.

3. The jet injector of claim 2, wherein the injector is configured for supporting the syringe body during the jet injection only from the proximal portion of the body, such that the distal portion of the body is substantially unsupported axially.

4. The jet injector of claim 2, wherein the injector is configured for supporting the syringe body substantially only from the flange during the jet injection, by the support and cushion, such that the distal portion of the body is substantially unsupported axially.

5. The jet injector of claim 2, wherein the support and cushion are configured for supporting substantially only the flange during the jet injection, such that the distal portion of the body is substantially unsupported axially.

6. The jet injector of claim 5, wherein the flange is of unitary construction with the body, which are made of glass.

7. The jet injector of claim 6, wherein the body further comprises a needle hub of unitary construction with the wall, the needle hub being adhered to the needle.

8. The jet injector of claim 2, wherein the support and cushion are configured for entirely supporting the syringe from the flange during the jet injection, such that the distal portion of the body is substantially unsupported axially.

9. The jet injector of claim 1, wherein the syringe support comprises a sleeve configured for receiving the wall axially therein, and the cushion has flange portion extending radially and disposed to interface axially between the flange and the sleeve for compensating for the shape irregularities and absorbing the shock from the injection.

10. The jet injector of claim 9, wherein the syringe body is made of blown glass.

11. The jet injector of claim 1, wherein the cushion comprises axially elevated portions of the resilient material configured for abutting the syringe flange.

12. The jet injector of claim 1, wherein the resilient material is an elastomeric material.

13. The jet injector of claim 1, wherein support is configured for supporting a prefilled syringe dimensioned such that the energy source produces the jet injection, using the needle as an injection-assisting needle.

14. The jet injector of claim 1, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains above about 90 p.s.i. and below about 500 p.s.i. during the injection of the medicament.

15. The jet injector of claim 1, wherein the energy source is configured to produce the injecting pressure that remains between about 100 p.s.i. and 350 p.s.i. during the injection of the medicament.

16. The jet injector of claim 1, further comprising: a housing that houses the syringe support and cushion, wherein the housing is configured for allowing insertion of the needle to penetration depth, which is between about 0.5 mm and 5 mm below the surface at the insertion location; and a ram in driven association with the energy source for driving the plunger into the body to expel the medicament; wherein the energy source and ram are configured to produce the injecting pressure sufficient for ejecting the medicament with sufficient velocity for delivery remote from the penetration depth of the needle by jet injection.

17. The jet injector of claim 1, further comprising a housing portion that houses the syringe support, the cushion, and the energy source, wherein syringe support and cushion are associated for holding the syringe body in a fixed position before and during activation of the energy source for firing of the jet injector.

18. The jet injector of claim 17, further comprising: a retractable guard that is movable with respect to the housing portion between: a protecting position in which the needle is disposed within the guard, and an injecting position in which the tip of the needle is exposed for insertion to the insertion point; and a trigger mechanism operably associated with the guard and energy source for activating the energy source to jet inject the medicament upon retraction of the guard to the injecting position.

19. The jet injector of claim 1, wherein the energy source comprises a spring, and the jet injector further comprises a ram that is biased by the spring against the plunger for driving the plunger into the body to expel the medicament, wherein the ram comprises a bell portion on which the spring is seated, and the bell portion defines a hollow interior configured for receiving the prefilled syringe and syringe support when the device is fired, such that the spring surrounds the prefilled syringe after the firing.

20. The jet injector of claim 1, further comprising the syringe held by the syringe support and cushion.

21. A jet injector, comprising: a prefilled syringe, that comprises: syringe body of unitary construction made of glass, comprising: a syringe wall defining a container portion defining a fluid chamber containing a medicament, a flange extending radially from a proximal portion of the syringe wall and shaped for grasping for injection by hand when the syringe is used independently, and a plunger movable within the fluid chamber to expel the medicament, and a needle disposed at the distal end of the syringe body, having an injection tip configured for piercing an insertion location, and defining a fluid pathway in fluid communication with the chamber for injecting the fluid expelled from the chamber into an injection site; a syringe support supporting the syringe body by the flange; an energy source configured for biasing the plunger with a force sufficient to produce an injecting pressure in the medicament in the chamber maintained between about 80 p.s.i. and 1000 p.s.i. during injection of the medicament to jet inject the medicament from the fluid chamber through the needle to the injection site; and a cushion associated with the syringe support and made of a sufficiently resilient material and configured to compensate for shape irregularities of the prefilled syringe and absorb shock on the flange from the jet injection to protect the flange from breaking.

22. The jet injector of claim 21, wherein the support and cushion are configured for supporting substantially only the flange during the jet injection, such that the distal portion of the body is substantially unsupported axially.

23. The jet injector of claim 21, wherein the body further comprises a needle hub of unitary construction with the wall, the needle hub being adhered to the needle.

24. The jet injector of claim 21, wherein the syringe body is made of blown glass.

25. The jet injector of claim 22, wherein the resilient material is an elastomeric material.

26. The jet injector of claim 21, further comprising a housing portion that houses the syringe support, the cushion, the syringe, and the energy source, wherein syringe support and cushion hold the syringe body in a fixed position before and during activation of the energy source for firing of the jet injector.

27. The jet injector of claim 21, further comprising: a housing that houses the syringe support and cushion, wherein the housing is configured for allowing insertion of the needle to penetration depth, which is between about 0.5 mm and 5 mm below the surface at the insertion location; and a ram in driven association with the energy source for driving the plunger into the body to expel the medicament; wherein the energy source and ram are configured to produce the injecting pressure sufficient for ejecting the medicament with sufficient velocity for delivery remote from the penetration depth of the needle by jet injection, thereby using the needle as an injection-assisting needle.

28. The jet injector of claim 21, wherein the energy source is configured to maintain the injecting pressure between about 100 p.s.i. and 350 p.s.i. during the injection of the medicament.
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