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Claims for Patent: 8,536,167

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Claims for Patent: 8,536,167

Title:Methods for treating ophthalmic, otic, or nasal infections
Abstract: The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.
Inventor(s): Stroman; David W. (Irving, TX), Chowhan; Masood A. (Arlington, TX), Appell; Kenneth C. (Burleson, TX)
Assignee: Alcon Research, Ltd. (Fort Worth, TX)
Application Number:12/829,973
Patent Claims: 1. A method for treating an ophthalmic, otic, or nasal infection comprising: treating the infection with a pharmaceutically effective amount of a composition comprising finafloxacin at a concentration of 0.1 to 1.0 w/v %.

2. A method according to claim 1 wherein said infection is a nasal infection.

3. A method according to claim 1 wherein said infection is acute otitis externa or acute otitis media with tympanostomy tubes.

4. A method according to claim 1 wherein said composition comprises finafloxacin or a pharmaceutically acceptable salt thereof at a concentration of 0.1 to 0.5 w/v %.

5. A method according to claim 1 wherein said composition comprises finafloxacin or a pharmaceutically acceptable salt thereof at a concentration of 0.3 to 0.4 w/v %.

6. A method according to claim 1, said composition having a pH of 5.0 to 7.5.

7. A method according to claim 1, said composition having a pH of 5.0 to 6.0.

8. A method according to claim 1, said composition further comprising an anti-inflammatory agent.

9. A method according to claim 8 wherein said anti-inflammatory agent is dexamethasone.

10. A method according to claim 1 wherein said infection is an otic infection.
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