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Claims for Patent: 8,536,150

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Claims for Patent: 8,536,150

Title:Methods of myocardial perfusion imaging
Abstract: The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopu- rin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.
Inventor(s): Belardinelli; Luiz (Palo Alto, CA), Blackburn; Brent K. (Los Altos, CA), Gao; Zhenhai (San Jose, CA)
Assignee: Gilead Sciences, Inc. (Foster City, CA)
Application Number:13/525,223
Patent Claims: 1. A method of myocardial perfusion imaging in a human in need thereof comprising: administering to the human (a) CVT-3146, also known as (1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminop- urin-2-yl}pyrazol-4-yl)-N-methylcarboxamide, in an amount of 0.2 to 9 .mu.g/kg by a single intravenous bolus dose of a liquid pharmaceutical composition comprising CVT-3146 and (b) a radionuclide, and thereafter determining areas of insufficient blood flow.

2. The method of claim 1, wherein the amount of CVT-3146 administered is 1 to 9 .mu.g/kg.

3. The method of claim 1, wherein the pharmaceutical composition is administered before the radionuclide is administered.
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