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|Abstract:||The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.|
|Inventor(s):||Olhava; Edward J. (Newton, MA), Danca; Mihaela Diana (Mendham, NJ)|
|Assignee:||Millennium Pharmaceuticals, Inc. (Cambridge, MA)|
1. A compound of formula (I): ##STR00009## or a boronic acid anhydride thereof, wherein: Z.sup.1 and Z.sup.2 are each hydroxy.
2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
3. A method of treating cancer, comprising treating a patient in need of such treatment with a compound according to claim 1.
4. A method of treating cancer, comprising treating a patient in need of such treatment with a pharmaceutical composition according to claim 2.