Claims for Patent: 8,518,437

Summary for Patent: 8,518,437

Title:	Lipid carrier compositions with enhanced blood stability
Abstract:	Liposomes that contain at least 10 mol % of a negatively charged lipid coupled to a non-zwitterionic moiety are stable in the blood. Liposomes containing at least 1 mol % of such lipids may be frozen safely.
Inventor(s):	Tardi; Paul (Surrey, CA), Webb; Murray (North Vancouver, CA), Mayer; Lawrence D. (North Vancouver, CA), Ickenstein; Ludger M. (Vancouver, CA)
Assignee:	Celator Pharmaceuticals, Inc. (Princeton, NJ)
Application Number:	10/294,474
Patent Claims:	1. A composition comprising liposomes that contain at least one biologically active agent wherein the ordered bilayer(s) of said liposomes consist(s) essentially of: (a) one or more vesicle forming lipids, which are phospholipids or sphingolipids such that; (b) at least 1 mol % of said bilayer(s) is phosphatidylglycerol (PG) and/or phosphatidylinositol (PI); (c) 5-20 mol % cholesterol; and wherein said liposomes have a mean diameter between 80-200 nm +/-25 nm; and have a transition temperature (T.sub.c) of at least 38.degree. C. which composition is cryostable in the absence of cryoprotectant.