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Claims for Patent: 8,512,717

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Claims for Patent: 8,512,717

Title:Compositions for delivery of therapeutics into the eyes and methods for making and using same
Abstract: The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.
Inventor(s): Vehige; Joseph G. (Laguna Niguel, CA), Chang; James N. (Newport Beach, CA), Graham; Richard (Irvine, CA), Lyons; Robert T. (Laguna Hills, CA), Kuan; Teresa H. (Placentia, CA), Chang; Chin-Ming (Tustin, CA)
Assignee: Allergan, Inc. (Irvine, CA)
Application Number:10/911,966
Patent Claims: 1. A topical ophthalmic solution for administering an anti-inflammatory to a human or animal suffering from ophthalmic inflammation, the solution consisting of: water; ketorolac, in a range of 0.01% to 1.0% w/v; a retention component in an amount effective to provide the topical ophthalmic composition with a viscosity greater than human tear fluid wherein the retention component consists of a mixture of medium molecular weight carboxymethyl cellulose and high molecular weight carboxymethyl cellulose wherein the medium and high molecular weight carboxymethyl cellulose have a weight ratio between 0.25 and 4 and is present in an amount of 0.1% to 2.0% w/v; sodium hydroxide and hydrochloric acid to adjust the pH; sodium chloride; a buffer; and having a pH in a range of about 6 to about 8.

2. The topical ophthalmic composition of claim 1 wherein the medium and high molecular weight carboxymethyl cellulose is sodium carboxymethyl cellulose.

3. A topical ophthalmic solution for administering an anti-inflammatory to a human or animal suffering from ophthalmic inflammation, the solution consisting of: water as the carrier component; ketorolac in the amount of 0.01% to 1.0% w/v of the solution; 0.1% to 2.0% w/v of a mixture of medium molecular weight carboxymethyl cellulose and high molecular weight carboxymethyl cellulose wherein the medium and high molecular weight carboxymethyl cellulose have a weight ratio between 0.25 and 4 and are present in an amount of 0.1% to 2.0% w/v; sodium chloride; a buffer; and sodium hydroxide and hydrochloric acid to adjust the solution to a pH in a range of about 6 to about 8.

4. A topical ophthalmic solution for treatment of pain and inflammation for ocular administration to a human consisting of: water; ketorolac in an amount of 0.01% to 1.0% w/v of the solution; 0.1% to 2.0% w/v of a mixture of medium molecular weight carboxymethyl cellulose and high molecular weight carboxymethyl cellulose wherein the medium and high molecular weight carboxymethyl cellulose have a weight ratio between 0.25 and 4 and is present in an amount of 0.1% to 2.0% w/v; sodium chloride; a buffer; and sodium hydroxide and hydrochloric acid to adjust the solution to a pH in a range of about 6 to about 8.

5. The solution of claim 3 wherein the sodium hydroxide and hydrochloric acid are 1 N.

6. The topical ophthalmic solution of claim 4 wherein the solution has a pH of about 6.8.
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