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Claims for Patent: 8,506,929

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Claims for Patent: 8,506,929

Title:Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
Abstract: This invention relates to a method of imaging amyloid deposits and to styrylpyridine compounds, and methods of making radiolabeled styrylpyridine compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
Inventor(s): Kung; Hank F. (Wynnewood, PA), Kung; Mei-Ping (Wynnewood, PA)
Assignee: The Trustees of the University of Pennsylvania (Philadelphia, PA)
Application Number:12/186,072
Patent Claims: 1. A compound of the formula: ##STR00039## wherein, R.sup.a and R.sup.b are independently hydrogen or methyl, and Z is --F or --.sup.18F.

2. The compound of claim 1 of the formula: ##STR00040##

3. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or diluent.

4. A composition comprising a compound of claim 2 and a pharmaceutically acceptable carrier or diluent.

5. A method of imaging amyloid deposits in a mammal, comprising: introducing into the mammal a detectable quantity of a compound of claim 1; allowing sufficient time for the compound to be associated with one or more amyloid deposits; and detecting the compound associated with one or more amyloid deposits.

6. A method of imaging amyloid deposits in a mammal, comprising: introducing into the mammal a detectable quantity of a composition of claim 3; allowing sufficient time for the compound to be associated with one or more amyloid deposits; and detecting the compound associated with one or more amyloid deposits.
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