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Claims for Patent: 8,499,757

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Claims for Patent: 8,499,757

Title:Dry powder inhaler and system for drug delivery
Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
Inventor(s): Smutney; Chad C. (Watertown, CT), Kinsey; P. Spencer (Sandy Hook, CT), Sahi; Carl R. (Coventry, CT), Adamo; Benoit (Mount Kisco, NY), Polidoro; John M. (Coventry, CT), McLean; Scott (Waterbury, CT), Overfield; Dennis (Fairfield, CT), Bryant; Anthony (Stratford, CT)
Assignee: MannKind Corporation (Valencia, CA)
Application Number:12/484,125
Patent Claims: 1. A dry powder inhaler comprising: a sled or slide tray, and a mouthpiece, wherein movement of the mouthpiece actuates movement of the sled or slide tray and the sled or slide tray is operably configured to move a container from a powder containment position to a dosing position, wherein the container has at least one opening configured as an inlet and at least one opening configured as an outlet.

2. The dry powder inhaler of claim 1, wherein the mouthpiece is configured to engage the moveable member.

3. The dry powder inhaler of claim 1, further comprising a housing.

4. The dry powder inhaler of claim 3, wherein the inhaler has a proximal end and a distal end, and the housing, mouthpiece and sled or slide tray are attached at the distal end of the inhaler; and the mouthpiece pivots on the housing to attain an open or loading position or a closed or dosing position.

5. The dry powder inhaler of claim 4, wherein the housing encloses the sled or slide tray.

6. The dry powder inhaler of claim 3, wherein the sled or slide tray is configured within or outside the housing.

7. The dry powder inhaler of claim 3, wherein the inhaler comprises a gear mechanism mounted in said inhaler housing.

8. The dry powder inhaler of claim 7, wherein the gear mechanism is configured with the moveable member.

9. The dry powder inhaler of claim 3, wherein the mouthpiece has a first inlet port, a second inlet port and an exit port, and is configured to be at a superior position over the housing.

10. The dry powder inhaler of claim 9, wherein the mouthpiece further has an internal volume extending from the first inlet port to the exit port greater than 0.2 cubic centimeters.

11. The dry powder inhaler of claim 3, wherein the housing comprises a mounting area for a container.

12. The dry powder inhaler of claim 11, wherein the mounting area is configured to receive and hold a container, wherein the container comprises a cartridge having keying surfaces to provide proper orientation to install the cartridge.

13. The dry powder inhaler of claim 11, wherein the mounting area has a beveled edge and a keying configuration to correspond to a cartridge configuration and direction of mounting of a cartridge onto the mounting area.

14. The dry powder inhaler of claim 3, wherein the housing has one or more openings to allow ambient air into its interior compartment.

15. The dry powder inhaler of claim 3, wherein the housing is substantially rectangular in shape and has an upper surface, side walls and a bottom wall forming an enclosure and comprises one or more flanges projecting in an upwardly direction from the upper surface of the housing.

16. The dry powder inhaler of claim 3, wherein the housing has a substantially rectangular, oval, circular, or square shape.

17. The dry powder inhaler of claim 3, wherein the housing comprises one or more grasping surfaces to allow handling of the inhaler.

18. The dry powder inhaler of claim 3, wherein the sled or slide tray is positioned between the mouthpiece and the housing.

19. The dry powder inhaler of claim 1, wherein the mouthpiece actuates the sled or slide tray by rotation.

20. The dry powder inhaler of claim 1, wherein the mouthpiece actuates the sled or slide tray by translation.

21. The dry powder inhaler of claim 1, wherein the dry powder inhaler is configured to attain an open or container loading position, and a closed or dosing position.

22. The dry powder inhaler of claim 1, wherein the mouthpiece actuates the sled or slide tray during movement between an open position and a closed position or from the closed position to the open position.

23. The dry powder inhaler of claim 1, wherein the inhaler is further configured to have rigid flow conduits.

24. The dry powder inhaler of claim 1, wherein the sled or slide tray is attached to the mouthpiece by a hinge mechanism.

25. The dry powder inhaler of claim 24, wherein the hinge mechanism comprises a gear or rack and pinion mechanism.

26. The dry powder inhaler of claim 1, wherein the sled or slide tray comprises a cam.

27. The dry powder inhaler of claim 1, wherein the dry powder inhaler is breath powered.

28. The dry powder inhaler of claim 1, further comprising a cover for the mouthpiece.

29. A dry inhaler comprising: a housing, a sled or slide tray, and a mouthpiece engageably attached to the housing, wherein the mouthpiece is operably configured to engage the sled or slide tray and move the sled or slide tray to then move a container from a powder containment position to a dosing position.

30. An inhaler comprising a container mounting area including a sled or slide tray configured to receive a container, and a mouthpiece having at least two inlet apertures and at least one exit aperture; wherein movement of the mouthpiece actuates movement of the sled or slide tray; and wherein one inlet aperture of the at least two inlet apertures is in fluid communication with the container area, and one of the at least two inlet apertures is in fluid communication with the at least one exit aperture via a flow path configured to bypass the container area.

31. The inhaler of claim 30, further comprising a container moveably attached to the mouthpiece.

32. The inhaler of claim 31, wherein the container and the mouthpiece are capable of forming a flow conduit through one of the at least two inlet apertures.

33. The inhaler of claim 31, wherein the container is moveable between one or more positions when attached to the container mounting area of the inhaler; said positions selected from the group consisting of a containment position, a dosing position and a discarding position.

34. The inhaler of claim 31, further comprising rigid flow conduits between the at least two inlet apertures and the at least one exit aperture.

35. The inhaler of claim 30, wherein the inhaler is a unit dose inhaler.

36. The inhaler of claim 30, wherein the inhaler further comprises one or more grasping surfaces configured for handling the inhaler for use.

37. The inhaler of claim 31, wherein the container further comprises a top or lid.

38. The inhaler of claim 30, wherein the sled or slide tray is capable of reconfiguring a container to one or more positions selected from the group consisting of a containment position, a dosing position and a discarding position.

39. The inhaler of claim 31, where in the container is moveable by translation or rotation.

40. The inhaler of claim 30, wherein the at least one exit aperture is positioned superior to the container area.

41. A dry powder inhaler, comprising: a mouthpiece; a sled or slide tray; a housing, a hinge, and a gear mechanism configured to effectuate movement of the sled or slide tray; wherein the mouthpiece and the housing are moveably attached by the hinge, and wherein movement of the mouthpiece actuates movement of the gear.

42. The dry powder inhaler of claim 41, wherein the inhaler is a unit dose inhaler.

43. The dry powder inhaler of claim 41, wherein the housing comprises a mounting area for loading a container.

44. The dry powder inhaler of claim 41, wherein the inhaler comprises a substantially rectangular body having one or more grasping surfaces.

45. The dry powder inhaler of claim 41, wherein the mouthpiece comprises a flow conduit having a first inlet port in fluid communication with the container mounting area and a second inlet port in fluid communication with ambient air, and an exit port.

46. The dry powder inhaler of claim 41, wherein the mouthpiece is configured to engage the housing and partially covers the housing.

47. The dry powder inhaler of claim 41, wherein the housing has a distal end, a proximal end, a top surface, a bottom surface and sides and comprises a cartridge mounting area within the top surface.

48. The dry powder inhaler of claim 45, wherein the mounting area has at least one keying surface.

49. The dry powder inhaler of claim 41, wherein the sled or slide tray is positioned within the housing.

50. The dry powder inhaler of claim 41, wherein the housing has one or more openings and one or more flanges at the distal end of the top surface.

51. The dry powder inhaler of claim 41, further comprising a cover on the mouthpiece.
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