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|Title:||Method for stabilizing anti-dementia drug|
|Abstract:||The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.|
|Inventor(s):||Ueki; Yosuke (Kakamigahara, JP), Suzuki; Yasuyuki (Kakamigahara, JP), Fujioka; Satoshi (Kakamigahara, JP)|
|Assignee:||Eisai R&D Management Co., Ltd. (Tokyo, JP)|
1. A pharmaceutical composition comprising donepezil or a pharmaceutically acceptable salt thereof, a water-insoluble high molecular weight basic substance, a high
molecular weight acidic substance for stabilizing donepezil or a pharmaceutically acceptable salt thereof, and a water-soluble sugar or sugar alcohol in an oral matrix type sustained-release composition, wherein the water-insoluble high molecular weight
basic substance is ethylcellulose in an amount of 12 to 32 percent by weight and the high molecular weight acidic substance is methacrylic acid-ethyl acrylate copolymer in an amount of 15.8 to 37 percent by weight.
2. The pharmaceutical composition according to claim 1, wherein the water-soluble sugar or sugar alcohol is lactose.
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