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Claims for Patent: 8,481,083

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Claims for Patent: 8,481,083

Title:Granular compositions of magnesium oxide and citric acid and uses thereof
Abstract: Compositions are provided that are useful for the preparation of a medicament. The compositions comprise granules having a layer of sodium picosulphate coated on potassium bicarbonate. Additional granules having a layer of magnesium oxide coated on a core of citric acid are also provided. The two types of granules may be combined to obtain mixtures (preferably homogeneous or substantially homogeneous mixtures) of the two types of granules, which are useful, e.g., as pharmaceutical compositions.
Inventor(s): Xu; Haijun (Zhongshan Port, CN), Diao; Tiejun (Zhongshan Port, CN)
Assignee: Ferring International Center S.A. (St-Prex, CH)
Application Number:12/677,857
Patent Claims: 1. A pharmaceutical composition comprising: (a) magnesium oxide coated granules which have a layer of magnesium oxide coated on a core of citric acid; and (b) sodium picosulphate coated granules having a spray-coated layer of sodium picosulphate coating a potassium bicarbonate core.

2. The pharmaceutical composition according to claim 1 wherein the thickness of the layer of magnesium oxide is 2 to 15 .mu.m.

3. The pharmaceutical composition according to claim 1 wherein the thickness of the layer of magnesium oxide is 5 to 10 .mu.m.

4. The pharmaceutical composition according to claim 1 wherein the magnesium oxide coated granules are between 450 and 800 .mu.m broad at their broadest point.

5. The pharmaceutical composition according to claim 1 wherein the magnesium oxide coated granules have a particle size between about 100 .mu.m and 900 .mu.m.

6. The pharmaceutical composition according to claim 1 wherein more than 85% of the magnesium oxide coated granules have a size between about 100 .mu.m and about 900 .mu.m.

7. The pharmaceutical composition according to claim 1 wherein less than 5% of the magnesium oxide coated granules have a size greater than about 900 .mu.m; or wherein less than 5% of the magnesium oxide coated granules have a size less than about 100 .mu.m.

8. The pharmaceutical composition according to claim 1, wherein the magnesium oxide and citric acid form magnesium citrate in solution.

9. The pharmaceutical composition according to claim 1, additionally comprising saccharin sodium.

10. The pharmaceutical composition according to claim 1, additionally comprising orange flavoring.

11. The pharmaceutical composition according to claim 1, additionally comprising saccharin sodium and orange flavoring.
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