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Generated: September 21, 2017

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Title:Phenyl-piperazine derivatives as serotonin reuptake inhibitors
Abstract: The invention provides compounds represented by the general formula I ##STR00001## wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
Inventor(s): Bang-Andersen; Benny (Copenhagen S, DK)
Assignee: H. Lundbeck A/S (Copenhagen-Valby, DK)
Application Number:13/367,065
Patent Claims: 1. A pharmaceutical composition comprising the compound 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine or a pharmaceutically acceptable acid addition salt thereof, and at least one pharmaceutically acceptable carrier or diluent.

2. A method for the treatment of an affective disorder in an animal, comprising administering to said animal an amount of the composition of claim 1 comprising a therapeutically effective amount of said compound.

3. The method of claim 2 wherein said animal is a human.

4. The method of claim 2 wherein said affective disorder is depression.

5. The method of claim 4 wherein said animal is a human.

6. The method of claim 2 wherein said affective disorder is an anxiety disorder.

7. The method of claim 6 wherein said animal is a human.

8. The method of claim 6 wherein said anxiety disorder is general anxiety disorder or panic disorder.

9. The method of claim 8 wherein said animal is a human.

10. The method of claim 2 wherein said affective disorder is obsessive compulsive disorder.

11. The method of claim 10 wherein said animal is a human.

12. A method for the treatment of an affective disorder in an animal, comprising administering a therapeutically effective amount of the compound 1-[-2-[2,4-dimethylphenylsulfanyl)phenyl]piperazine or a pharmaceutically acceptable acid addition salt thereof to said animal.

13. The method of claim 12 wherein said animal is a human.

14. The method of claim 12 wherein said affective disorder is depression.

15. The method of claim 14 wherein said animal is a human.

16. The method of claim 12 wherein said affective disorder is an anxiety disorder.

17. The method of claim 16 wherein said animal is a human.

18. The method of claim 16 wherein said anxiety disorder is general anxiety disorder or panic disorder.

19. The method of claim 18 wherein said animal is a human.

20. The method of claim 12 wherein said affective disorder is obsessive compulsive disorder.

21. The method of claim 20 wherein said animal is a human.
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