Claims for Patent: 8,461,330

Summary for Patent: 8,461,330

Title:	Imidazotriazines and imidazopyrimidines as kinase inhibitors
Abstract:	The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
Inventor(s):	Zhuo; Jincong (Boothwyn, PA), Xu; Meizhong (Hockessin, DE), He; Chunhong (Boothwyn, PA), Zhang; Colin (Ambler, PA), Qian; Ding-Quan (Newark, DE), Burns; David M. (Philadelphia, PA), Li; Yun-Long (Chadds Ford, PA), Metcalf; Brian (Moraga, CA), Yao; Wenqing (Kennett Square, PA)
Assignee:	Incyte Corporation (Wilmington, DE)
Application Number:	12/813,148
Patent Claims:	1. A compound of Formula I: ##STR00226## or pharmaceutically acceptable salt thereof, wherein: A is N; and Cy.sup.1 is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, each optionally substituted by 1, 2, 3, 4, or 5-W-X-Y-Z groups; Cy.sup.2 is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, each optionally substituted by 1, 2, 3, 4, or 5-W'-X'-Y'-Z' groups; L.sup.1 is CH.sub.2, CH.sub.2CH.sub.2, cycloalkylene, (CR.sup.4R.sup.5).sub.pO(CR.sup.4R.sup.5).sub.q or (CR.sup.4R.sup.5).sub.pS(CR.sup.4R.sup.5).sub.q wherein said cycloalkylene is optionally substituted with 1, 2, or 3 substituents independently selected from Cy.sup.3, halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a, SR.sup.a, C(O)R.sup.b, C(O)NR.sup.cR.sup.d, C(O)OR.sup.a, OC(O)R.sup.b, OC(O)NR.sup.cR.sup.d, NR.sup.cR.sup.d, NR.sup.cC(O)R.sup.b, NR.sup.cC(O)NR.sup.cR.sup.d, NR.sup.cC(O)OR.sup.a, C(.dbd.NR.sup.g)NR.sup.cR.sup.d, NR.sup.cC(.dbd.NR.sup.g)NR.sup.cR.sup.d, P(R.sup.f).sub.2, P(OR.sup.e).sub.2, P(O)R.sup.eR.sup.f, P(O)OR.sup.eOR.sup.f, S(O)R.sup.b, S(O)NR.sup.cR.sup.d, S(O).sub.2R.sup.b, NR.sup.cS(O).sub.2R.sup.b, and S(O).sub.2NR.sup.cR.sup.d; L.sup.2 is (CR.sup.7R.sup.8).sub.r, (CR.sup.7R.sup.8).sub.s-(cycloalkylene)-(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.s-(arylene)-(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.s-(heterocycloalkylene)-(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.s-(heteroarylene)-(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sO(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sS(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sC(O)(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sC(O)NR.sup.9(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sC(O)O(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sOC(O)(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sOC(O)NR.sup.9(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sNR.sup.9(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sNR.sup.9C(O)NR.sup.9(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sS(O)(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.sS(O)NR.sup.7(CR.sup.8R.sup.9).sub.t, (CR.sup.7R.sup.8).sub.sS(O).sub.2(CR.sup.7R.sup.8).sub.t, or (CR.sup.7R.sup.8).sub.sS(O).sub.2NR.sup.9(CR.sup.7R.sup.8).sub.t, wherein said cycloalkylene, arylene, heterocycloalkylene, or heteroarylene is optionally substituted with 1, 2, or 3 substituents independently selected from Cy.sup.4, halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halo sulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a1, SR.sup.a1, C(O)R.sup.b1, C(O)NR.sup.c1R.sup.d1, C(O)OR.sup.a1, OC(O)R.sup.b1, OC(O)NR.sup.c1R.sup.d1, NR.sup.c1R.sup.d1, NR.sup.c1C(O)R.sup.b1, NR.sup.c1C(O)NR.sup.c1R.sup.d1, NR.sup.c1C(O)OR.sup.a1, C(.dbd.NR.sup.g)NR.sup.c1R.sup.d1, NR.sup.c1C(.dbd.NR.sup.g)NR.sup.c1R.sup.d1, P(R.sup.f1).sub.2, P(OR.sup.e1).sub.2, P(O)R.sup.e1R.sup.f1, P(O)OR.sup.e1OR.sup.f1, S(O)R.sup.b1, S(O)NR.sup.c1R.sup.d1, S(O).sub.2R.sup.b1, NR.sup.c1S(O).sub.2R.sup.b1, and S(O).sub.2NR.sup.c1R.sup.d1; R.sup.1 is H or -W''-X''-Y''-Z''; R.sup.2 is H, halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, CN, NO.sub.2, OR.sup.A, SR.sup.A, C(O)R.sup.B, C(O)NR.sup.CR.sup.D, C(O)OR.sup.A, OC(O)R.sup.B, OC(O)NR.sup.CR.sup.D, NR.sup.CR.sup.D, NR.sup.CC(O)R.sup.B, NR.sup.CC(O)NR.sup.CR.sup.D, NR.sup.CC(O)OR.sup.A, S(O)R.sup.B, S(O)NR.sup.CR.sup.D, S(O).sub.2R.sup.B, NR.sup.CS(O).sub.2R.sup.B, or S(O).sub.2NR.sup.CR.sup.D; or R.sup.2 and -L.sup.2-Cy.sup.2 are linked together to form a group of formula: ##STR00227## wherein ring B is a fused aryl or fused heteroaryl ring, each optionally substituted with 1, 2, or 3-W'-X'-Y'-Z' groups; R.sup.4 and R.sup.5 are independently selected from H, halo, OH, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 alkoxy, alkoxyalkyl, cyanoalkyl, heterocycloalkyl, cycloalkyl, C.sub.1-6 haloalkyl, CN, and NO.sub.2; or R.sup.4 and R.sup.5 together with the C atom to which they are attached form a 3, 4, 5, 6, or 7-membered cycloalkyl or heterocycloalkyl ring, each optionally substituted by 1, 2, or 3 substituents independently selected from halo, OH, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 alkoxy, alkoxyalkyl, cyanoalkyl, heterocycloalkyl, cycloalkyl, C.sub.1-6 haloalkyl, CN, and NO.sub.2; R.sup.7 and R.sup.8 are independently selected from H, halo, OH, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, CN, and NO.sub.2; or R.sup.7 and R.sup.8 together with the C atom to which they are attached form a 3, 4, 5, 6, or 7-membered cycloalkyl or heterocycloalkyl ring, each optionally substituted by 1, 2, or 3 substituent independently selected from halo, OH, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, CN, and NO.sub.2; R.sup.9 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, or C.sub.2-6 alkynyl; W, W', and W'' are independently absent or independently selected from C.sub.1-6 alkylene, C.sub.2-6 alkenylene, C.sub.2-6 alkynylene, O, S, NR.sup.h, CO, COO, CONR.sup.h, SO, SO.sub.2, SONR.sup.h and NR.sup.hCONR.sup.i, wherein each of the C.sub.1-6 alkylene, C.sub.2-6 alkenylene, and C.sub.2-6 alkynylene is optionally substituted by 1, 2 or 3 substituents independently selected from halo, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, OH, C.sub.1-6 alkoxy, C.sub.1-6 haloalkoxy, amino, C.sub.1-6 alkylamino, and C.sub.2-8 dialkylamino; X, X', and X'' are independently absent or independently selected from C.sub.1-6 alkylene, C.sub.2-6 alkenylene, C.sub.2-6 alkynylene, arylene, cycloalkylene, heteroarylene, and heterocycloalkylene, wherein each of the C.sub.1-6 alkylene, C.sub.2-6 alkenylene, C.sub.2-6 alkynylene, arylene, cyclo alkylene, heteroarylene, and heterocycloalkylene is optionally substituted by 1, 2 or 3 substituents independently selected from halo, CN, NO.sub.2, OH, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-8 alkoxyalkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkoxy, C.sub.2-8 alkoxyalkoxy, cycloalkyl, heterocycloalkyl, C(O)OR.sup.j, C(O)NR.sup.hR.sup.i, amino, C.sub.1-6 alkylamino, and C.sub.2-8 dialkylamino; Y, Y', and Y'' are independently absent or independently selected from C.sub.1-6 alkylene, C.sub.2-6 alkenylene, C.sub.2-6 alkynylene, O, S, NR.sup.h, CO, COO, CONR.sup.h, SO, SO.sub.2, SONR.sup.h, and NR.sup.hCONR.sup.i, wherein each of the C.sub.1-6 alkylene, C.sub.2-6 alkenylene, and C.sub.2-6 alkynylene is optionally substituted by 1, 2 or 3 substituents independently selected from halo, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, OH, C.sub.1-6 alkoxy, C.sub.1-6 haloalkoxy, amino, C.sub.1-6 alkylamino, and C.sub.2-8 dialkylamino; Z, Z', and Z'' are independently selected from H, halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a2, SR.sup.a2, C(O)R.sup.b2, C(O)NR.sup.c2R.sup.d2, C(O)OR.sup.a2, OC(O)R.sup.b2, OC(O)NR.sup.c2R.sup.d2, NR.sup.c2R.sup.d2, NR.sup.c2C(O)R.sup.b2, NR.sup.c2C(O)NR.sup.c2R.sup.d2, NR.sup.c2C(O)OR.sup.a2, C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, NR.sup.c2C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, P(R.sup.f2).sub.2, P(OR.sup.e2).sub.2, P(O)R.sup.e2R.sup.f2, P(O)OR.sup.e2OR.sup.f2, S(O)R.sup.b2, S(O)NR.sup.c2R.sup.d2, S(O).sub.2R.sup.b2, NR.sup.c2S(O).sub.2R.sup.b2, S(O).sub.2NR.sup.c2R.sup.d2, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl, wherein said C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl are optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a2, SR.sup.a2, C(O)R.sup.b2, C(O)NR.sup.c2R.sup.d2, C(O)OR.sup.a2, OC(O)R.sup.b2, OC(O)NR.sup.c2R.sup.d2, NR.sup.c2R.sup.d2, NR.sup.c2C(O)R.sup.b2, NR.sup.c2C(O)NR.sup.c2R.sup.d2, NR.sup.c2C(O)OR.sup.a2, C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, NR.sup.e2C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, P(R.sup.f2).sub.2, P(OR.sup.e2).sub.2, P(O)R.sup.e2R.sup.f2, P(O)OR.sup.e2OR.sup.f2, S(O)R.sup.b2, S(O)NR.sup.c2R.sup.d2, S(O).sub.2R.sup.b2, NR.sup.c2S(O).sub.2R.sup.b2, and S(O).sub.2NR.sup.c2R.sup.d2; wherein two adjacent -W-X-Y-Z groups, together with the atoms to which they are attached, optionally form a fused 4-20 membered cycloalkyl ring or a fused 4-20 membered heterocycloalkyl ring, each optionally substituted by 1, 2, or 3 substituents independently selected from halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, OR.sup.a3, SR.sup.a3, C(O)R.sup.b3, C(O)NR.sup.c3R.sup.d3, C(O)OR.sup.a3, OC(O)R.sup.b3, OC(O)NR.sup.c3R.sup.d3, NR.sup.c3R.sup.d3, NR.sup.c3C(O)R.sup.b3, NR.sup.c3C(O)NR.sup.c3R.sup.d3, NR.sup.c3C(O)OR.sup.a3, C(.dbd.NR.sup.g)NR.sup.c3R.sup.d3 NR.sup.c3C(.dbd.NR.sup.g)NR.sup.c3R.sup.d3S(O)R.sup.b3, S(O)NR.sup.c3R.sup.d3, S(O).sub.2R.sup.b3, NR.sup.c3S(O).sub.2R.sup.b3, S(O).sub.2NR.sup.c3R.sup.d3, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl; wherein two adjacent -W'-X'-Y'-Z' groups, together with the atoms to which they are attached, optionally form a fused 4-20 membered cycloalkyl ring or a fused 4-20 membered heterocycloalkyl ring, each optionally substituted by 1, 2, or 3 substituents independently selected from halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, OR.sup.a3, SR.sup.a3, C(O)R.sup.b3, C(O)NR.sup.c3R.sup.d3, C(O)OR.sup.a3, OC(O)R.sup.b3, OC(O)NR.sup.c3R.sup.d3, NR.sup.c3R.sup.d3, NR.sup.c3C(O)R.sup.b3, NR.sup.c3C(O)NR.sup.c3R.sup.d3, NR.sup.c3C(O)OR.sup.a3, C(.dbd.NR.sup.g)NR.sup.c3R.sup.d3, NR.sup.c3C(.dbd.NR.sup.g)NR.sup.c3R.sup.d3S(O)R.sup.b3, S(O)NR.sup.c3R.sup.d3, S(O).sub.2R.sup.b3, NR.sup.c3S(O).sub.2R.sup.b3, S(O).sub.2NR.sup.c3R.sup.d3, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl; Cy.sup.3 and Cy.sup.4 are independently selected from aryl, cycloalkyl, heteroaryl, and heterocycloalkyl, each optionally substituted by 1, 2, 3, 4, or 5 substituents independently selected from halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a4, SR.sup.a4, C(O)R.sup.b4, C(O)NR.sup.c4R.sup.d4, C(O)OR.sup.a4, OC(O)R.sup.b4, OC(O)NR.sup.c4R.sup.d4, NR.sup.c4R.sup.d4, NR.sup.c4C(O)R.sup.b4, NR.sup.c4C(O)NR.sup.c4R.sup.d4, NR.sup.c4C(O)OR.sup.a4, C(.dbd.NR.sup.g)NR.sup.c4R.sup.d4, NR.sup.c4C(.dbd.NR.sup.g)NR.sup.c4R.sup.d4, P(R.sup.f4).sub.2, P(OR.sup.4).sub.2, P(O)R.sup.e4R.sup.f4, P(O)OR.sup.e4OR.sup.f4, S(O)R.sup.b4, S(O)NR.sup.c4R.sup.d4, S(O).sub.2R.sup.b4, NR.sup.c4S(O).sub.2R.sup.b4, and S(O).sub.2NR.sup.c4R.sup.d4; R.sup.A is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl wherein said C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, and C.sub.1-4 alkyl; R.sup.B is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl wherein said C.sub.1-4 alkyl, C.sub.2-4 alkenyl, or C.sub.2-4 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, and C.sub.1-4 alkyl; R.sup.C and R.sup.D are independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, or C.sub.2-4 alkynyl, wherein said C.sub.1-4 alkyl, C.sub.2-4 alkenyl, or C.sub.2-4 alkynyl, is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, and C.sub.1-4 alkyl; or R.sup.C and R.sup.D together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group or heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, and C.sub.1-4 alkyl; R.sup.a, R.sup.a1, R.sup.a2, R.sup.a3, and R.sup.a4 are independently selected from H, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, wherein said C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, and C.sub.1-6 haloalkoxy; R.sup.b, R.sup.b1, R.sup.b2, R.sup.b3, and R.sup.b4 are independently selected from H, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, wherein said C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, and C.sub.1-6 haloalkoxy; R.sup.c and R.sup.d are independently selected from H, C.sub.1-10 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C.sub.1-10 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, and C.sub.1-6 haloalkoxy; or R.sup.c and R.sup.d together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group or heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, and C.sub.1-6 haloalkoxy; R.sup.c1 and R.sup.d1 are independently selected from H, C.sub.1-10 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C.sub.1-10 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, and C.sub.1-6 haloalkoxy; or R.sup.c1 and R.sup.d1 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group or heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, and C.sub.1-6 haloalkoxy; R.sup.c2 and R.sup.d2 are independently selected from H, C.sub.1-10 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkyl, arylheterocycloalkyl, arylheteroaryl, biaryl, heteroarylcycloalkyl, heteroarylheterocycloalkyl, heteroarylaryl, and biheteroaryl, wherein said C.sub.1-10 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkyl, arylheterocycloalkyl, arylheteroaryl, biaryl, heteroarylcycloalkyl, heteroarylheterocycloalkyl, heteroarylaryl, and biheteroaryl are each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, C.sub.1-6 haloalkoxy, hydroxyalkyl, cyanoalkyl, aryl, heteroaryl, C(O)OR.sup.a4, C(O)R.sup.b4, S(O).sub.2R.sup.b3, alkoxyalkyl, and alkoxyalkoxy; or R.sup.c2 and R.sup.d2 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group or heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, C.sub.1-6 haloalkoxy, hydroxyalkyl, cyanoalkyl, aryl, heteroaryl, C(O)OR.sup.a4, C(O)R.sup.b4, S(O).sub.2R.sup.b3, alkoxyalkyl, and alkoxyalkoxy; R.sup.c3 and R.sup.d3 are independently selected from H, C.sub.1-10 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C.sub.1-10 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, and C.sub.1-6 haloalkoxy; or R.sup.c3 and R.sup.d3 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group or heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, and C.sub.1-6 haloalkoxy; R.sup.c4 and R.sup.d4 are independently selected from H, C.sub.1-10 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C.sub.1-10 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, and C.sub.1-6 haloalkoxy; or R.sup.c4 and R.sup.d4 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group or heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, and C.sub.1-6 haloalkoxy; R.sup.e, R.sup.e1, R.sup.e2, and R.sup.e4 are independently selected from H, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, (C.sub.1-6 alkoxy)-C.sub.1-6 alkyl, C.sub.2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, and heterocycloalkylalkyl; R.sup.f, R.sup.f1, R.sup.f2, and R.sup.f4 are independently selected from H, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl; R.sup.g is H, CN, and NO.sub.2; R.sup.h and R.sup.i are independently selected from H and C.sub.1-6 alkyl; R.sup.j is H, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl; p is 0, 1, 2, 3, or 4; q is 0, 1, 2, 3, or 4; r is 0, 1, 2, 3, 4, 5, or 6; s is 0, 1, 2, 3, or 4; and t is 0, 1, 2, 3, or 4. 2. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein Cy.sup.1 is aryl or heteroaryl, each optionally substituted by 1, 2, 3, 4, or 5-W-X-Y-Z groups. 3. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein Cy.sup.1 is quinolinyl optionally substituted by 1, 2, 3, 4, or 5-W-X-Y-Z groups. 4. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein Cy.sup.2 is aryl or heteroaryl, each optionally substituted by 1, 2, 3, 4, or 5-W'-X'-Y'-Z' groups. 5. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein Cy.sup.2 is aryl or heteroaryl, each optionally substituted by 1, 2, 3, 4, or 5-W'-X'-Y'-Z' groups wherein at least one of said -W'-X'-Y'-Z' groups is C(O)NR.sup.c2R.sup.d2. 6. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein L.sup.1 is CH.sub.2. 7. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein L.sup.1 is cycloalkylene. 8. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein L.sup.1 is (CR.sup.4R.sup.5).sub.pO(CR.sup.4R.sup.5).sub.q or (CR.sup.4R.sup.5).sub.pS(CR.sup.4R.sup.5).sub.q. 9. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein L.sup.1 is O or S. 10. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein L.sup.2 is (CR.sup.7R.sup.8).sub.r. 11. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein L.sup.2 is (CR.sup.7R.sup.8).sub.r, (CR.sup.7R.sup.8).sub.s-(cycloalkylene)-(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.s-(arylene)-(CR.sup.7R.sup.8).sub.t, (CR.sup.7R.sup.8).sub.s-(heterocycloalkylene)-(CR.sup.7R.sup.8).sub.t, or (CR.sup.7R.sup.8).sub.s-(heteroarylene)-(CR.sup.7R.sup.8).sub.t, wherein said cycloalkylene, arylene, heterocycloalkylene, or heteroarylene is optionally substituted with 1, 2, or 3 substituents independently selected from Cy.sup.4, halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a1, SR.sup.a1, C(O)R.sup.b1, C(O)NR.sup.c1R.sup.d1, C(O)OR.sup.a1, OC(O)R.sup.b1, OC(O)NR.sup.c1R.sup.d1, NR.sup.c1R.sup.d1, NR.sup.c1C(O)R.sup.b1, NR.sup.c1C(O)NR.sup.c1R.sup.d1, NR.sup.c1C(O)OR.sup.a1, C(.dbd.NR.sup.g)NR.sup.c1R.sup.d1, NR.sup.c1C(.dbd.NR.sup.g)NR.sup.c1R.sup.d1, P(R.sup.f1).sub.2, P(OR.sup.e1).sub.2, P(O)R.sup.e1R.sup.f1, P(O)OR.sup.e1OR.sup.f1, S(O)R.sup.b1, S(O)NR.sup.c1R.sup.d1, S(O).sub.2R.sup.b1, NR.sup.c1S(O).sub.2R.sup.b1, and S(O).sub.2NR.sup.c1R.sup.d1. 12. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein L.sup.2 is (CR.sup.7R.sup.8).sub.r, (CR.sup.7R.sup.8).sub.s-(cycloalkylene)-(CR.sup.7R.sup.8).sub.t or (CR.sup.7R.sup.8).sub.s-(arylene)-(CR.sup.7R.sup.8).sub.t, wherein said cycloalkylene or arylene, is optionally substituted with 1, 2, or 3 substituents independently selected from Cy.sup.4, halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a1, SR.sup.a1, C(O)R.sup.b1, C(O)NR.sup.c1R.sup.d1, C(O)OR.sup.a1, OC(O)R.sup.b1, OC(O)NR.sup.c1R.sup.d1, NR.sup.c1R.sup.d1, NR.sup.c1C(O)R.sup.b1, NR.sup.c1C(O)NR.sup.c1R.sup.d1, NR.sup.c1C(O)OR.sup.a1, C(.dbd.NR.sup.g)NR.sup.c1R.sup.d1, NR.sup.c1C(.dbd.NR.sup.g)NR.sup.c1R.sup.d1, P(R.sup.f1).sub.2, P(OR.sup.e1).sub.2, P(O)R.sup.e1R.sup.f1, P(O)OR.sup.e1OR.sup.f1, S(O)R.sup.b1, S(O)NR.sup.c1R.sup.d1, S(O).sub.2R.sup.b1, NR.sup.c1S(O).sub.2R.sup.b1 and S(O).sub.2NR.sup.c1R.sup.d1. 13. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein L.sup.2 is (CR.sup.7R.sup.8).sub.s-(cycloalkylene)-(CR.sup.7R.sup.8).sub.t or (CR.sup.7R.sup.8).sub.s-(arylene)-(CR.sup.7R.sup.8).sub.t, wherein said cycloalkylene or arylene, is optionally substituted with 1, 2, or 3 substituents independently selected from Cy.sup.4, halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a1, SR.sup.a1, C(O)R.sup.b1, C(O)NR.sup.c1R.sup.d1, C(O)OR.sup.a1, OC(O)R.sup.b1, OC(O)NR.sup.c1R.sup.d1, NR.sup.c1R.sup.d1, NR.sup.c1C(O)R.sup.b1, NR.sup.c1C(O)NR.sup.c1R.sup.d1, NR.sup.c1C(O)OR.sup.a1, C(.dbd.NR.sup.g)NR.sup.c1R.sup.d1, NR.sup.c1C(.dbd.NR.sup.g)NR.sup.c1R.sup.d1, P(R.sup.f1).sub.2, P(OR.sup.e1).sub.2, P(O)R.sup.e1R.sup.f1, P(O)OR.sup.e1OR.sup.f1, S(O)R.sup.b1, S(O)NR.sup.c1R.sup.d1, S(O).sub.2R.sup.b1, NR.sup.c1S(O).sub.2R.sup.b1, and S(O).sub.2NR.sup.c1R.sup.d1. 14. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein L.sup.2 is cycloalkylene or arylene. 15. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein Cy.sup.2 is cycloalkyl optionally substituted by 1, 2, 3, 4, or 5-W'-X'-Y'-Z' groups. 16. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein Cy.sup.2 is heterocycloalkyl optionally substituted by 1, 2, 3, 4, or 5-W'-X'-Y'-Z' groups. 17. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein R.sup.1 is H, R.sup.2 is H, R.sup.4 is H, R.sup.5 is H, R.sup.7 is H, R.sup.8 is H, and R.sup.9 is H. 18. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein the -W-X-Y-Z group is halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a2, SR.sup.a2, C(O)R.sup.b2, C(O)NR.sup.c2R.sup.d2, C(O)OR.sup.a2, OC(O)R.sup.b2, OC(O)NR.sup.c2R.sup.d2, NR.sup.c2R.sup.d2, NR.sup.c2C(O)R.sup.b2, NR.sup.c2C(O)NR.sup.c2R.sup.d2, NR.sup.c2C(O)OR.sup.a2, C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, NR.sup.c2C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, P(R.sup.f2).sub.2, P(OR.sup.e2).sub.2, P(O)R.sup.e2R.sup.f2, P(O)OR.sup.e2OR.sup.f2, S(O)R.sup.b2, S(O)NR.sup.c2R.sup.d2, S(O).sub.2R.sup.b2, NR.sup.c2S(O).sub.2R.sup.b2, S(O).sub.2NR.sup.c2R.sup.d2, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl, wherein said C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl are optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a2, SR.sup.a2, C(O)R.sup.b2, C(O)NR.sup.c2R.sup.d2, C(O)OR.sup.a2, OC(O)R.sup.b2, OC(O)NR.sup.c2R.sup.d2, NR.sup.c2R.sup.d2, NR.sup.c2C(O)R.sup.b2, NR.sup.c2C(O)NR.sup.c2R.sup.d2, NR.sup.c2C(O)OR.sup.a2, C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, NR.sup.c2C(NR.sup.g)NR.sup.c2R.sup.d2, P(R.sup.f2).sub.2, P(OR.sup.e2).sub.2, P(O)R.sup.e2R.sup.f2, P(O)OR.sup.e2OR.sup.f2, S(O)R.sup.b2, S(O)NR.sup.c2R.sup.d2, S(O).sub.2R.sup.b2, NR.sup.c2S(O).sub.2R.sup.b2, and S(O).sub.2NR.sup.c2R.sup.d2. 19. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein the -W'-X'-Y'-Z' group is halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a2, SR.sup.a2, C(O)R.sup.b2, C(O)NR.sup.c2R.sup.d2, C(O)OR.sup.a2, OC(O)R.sup.b2, OC(O)NR.sup.c2R.sup.d2, NR.sup.c2R.sup.d2, NR.sup.c2C(O)R.sup.b2, NR.sup.c2C(O)NR.sup.c2R.sup.d2, NR.sup.c2C(O)OR.sup.a2, C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, NR.sup.c2C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, P(R.sup.f2).sub.2, P(OR.sup.e2).sub.2, P(O)R.sup.e2R.sup.f2, P(O)OR.sup.e2OR.sup.f2, S(O)R.sup.b2, S(O)NR.sup.c2R.sup.d2, S(O).sub.2R.sup.b2, NR.sup.c2S(O).sub.2R.sup.b2, S(O).sub.2NR.sup.c2R.sup.d2, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl, wherein said C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl are optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, halosulfanyl, CN, NO.sub.2, N.sub.3, OR.sup.a2, SR.sup.a2, C(O)R.sup.b2, C(O)NR.sup.c2R.sup.d2, C(O)OR.sup.a2, OC(O)R.sup.b2, OC(O)NR.sup.c2R.sup.d2, NR.sup.c2R.sup.d2, NR.sup.c2C(O)R.sup.b2, NR.sup.c2C(O)NR.sup.c2R.sup.d2, NR.sup.c2C(O)OR.sup.a2, C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, NR.sup.c2C(.dbd.NR.sup.g)NR.sup.c2R.sup.d2, P(R.sup.f2).sub.2, P(OR.sup.e2).sub.2, P(O)R.sup.e2R.sup.f2, P(O)OR.sup.e2OR.sup.f2, S(O)R.sup.b2, S(O)NR.sup.c2R.sup.d2, S(O).sub.2R.sup.b2, NR.sup.c2S(O).sub.2R.sup.b2, and S(O).sub.2NR.sup.c2R.sup.d2. 20. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula IIa: ##STR00228## 21. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula III: ##STR00229## 22. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula VIII: ##STR00230## 23. A composition comprising a compound of claim 1, or pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier. 24. A method of treating a cancer in a patient comprising administering to said patient a therapeutically effective amount of a compound of claim 1, or pharmaceutically acceptable salt thereof, wherein said cancer is breast cancer. 25. A method of treating breast cancer in a patient comprising administering to said patient a therapeutically effective amount of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-- 2-yl]benzamide or pharmaceutically acceptable salt thereof.