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Claims for Patent: 8,440,722

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Claims for Patent: 8,440,722

Title:Methods for concomitant administration of colchicine and a second active agent
Abstract: Methods for concomitant administration of colchicine together with one or more second active agents, e.g., verapamil, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for concomitant administration of colchicine together with second active agents are also provided.
Inventor(s): Davis; Matthew W. (Erwinna, PA)
Assignee: Takeda Pharamceuticals U.S.A., Inc. (Deerfield, IL)
Application Number:13/454,255
Patent Claims: 1. A method of treating a patient in need of treatment for prophylaxis of gout flares with colchicine, comprising orally administering an adjusted daily dosage amount of colchicine to the patient who is receiving concomitant administration of verapamil, wherein the adjusted daily dosage amount of colchicine is 50% to 75% of an intended daily dosage amount of colchicine, wherein the intended daily dosage amount of colchicine is a dosage amount suitable for the patient if the patient were not receiving concomitant verapamil, wherein the intended daily dosage amount of colchicine suitable for the patient if the patient were not receiving concomitant verapamil is 0.6 mg twice daily or 0.6 mg once daily, and wherein the concomitantly administered dose of verapamil is 240 mg per day.

2. The method of claim 1, wherein the adjusted daily dosage amount is 50% of the intended daily dosage amount.
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