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|Title:||Methods for concomitant administration of colchicine and a second active agent|
|Abstract:||Methods for concomitant administration of colchicine together with one or more second active agents, e.g., ketoconazole and ritonavir, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for concomitant administration of colchicine together with second active agents are also provided.|
|Inventor(s):||Davis; Matthew W. (Erwinna, PA)|
|Assignee:||Takeda Pharmaceuticals U.S.A., Inc. (Deerfield, IL)|
1. A method of treating a patient in need of treatment for acute gout flares with colchicine, comprising orally administering an adjusted daily dosage amount of colchicine
to the patient who is receiving concomitant administration of verapamil, wherein the adjusted daily dosage amount of colchicine is 50% to 75% of an intended daily dosage amount of colchicine, wherein the intended daily dosage amount of colchicine is a
dosage amount suitable for the patient if the patient were not receiving concomitant verapamil, wherein the intended daily dosage amount of colchicine suitable for the patient if the patient were not receiving concomitant verapamil is 1.2 mg at the first
sign of flare, followed by 0.6 mg one hour later, and wherein the concomitantly administered dose of verapamil is 240 mg per day.
2. The method of claim 1, wherein the dose is not to be repeated for 3 days.
3. The method of claim 1, wherein the adjusted daily dosage amount of colchicine is 1.2 mg.
4. The method of claim 3, wherein the dose is not to be repeated for 3 days.
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