DrugPatentWatch Database PreviewSee Plans and Pricing
« Back to Dashboard
Summary for Patent: 8,436,010
|Title:||Treatment of solid tumors with rapamycin derivatives|
|Abstract:||Rapamycin derivatives have interesting effects in the treatment of solid tumors, optionally in combination with a chemotherapeutic agent.|
|Inventor(s):||Lane; Heidi (Basel, CH), O'Reilly; Terence (Basel, CH), Wood; Jeanette Marjorie (Biel-Benken, CH)|
|Assignee:||Novartis Pharmaceuticals Corporation (East Hanover, NJ)|
|Patent Litigation and PTAB cases:||See patent lawsuits and PTAB cases for patent 8,436,010|
1. A method for inhibiting growth of solid tumors of the breast in a subject having a solid breast tumor, said method consisting of administering to said subject a
therapeutically effective amount of a compound of formula I concomitantly or sequentially with exemestane, ##STR00002## wherein R.sub.1 is CH.sub.3, R.sub.2 is --CH.sub.2--CH.sub.2--OH, and X is .dbd.O.
2. The method of claim 1 wherein the solid tumor of the breast has metastasized.
3. The method of claim 1 wherein the compound of formula I and the exemestane are administered orally.
4. The method of claim 1 wherein the compound of formula I is administered at a daily dose range of from about 0.1 to 25 mg, as a single dose or in divided doses.
5. The method of claim 1 wherein the compound of formula I is administered in a unit dosage form of from about 0.05 to 12.5 mg.
6. The method of claim 5 wherein the compound of formula I is administered in a unit dosage form of from about 0.25 to 10 mg.
7. The method of claim 6 wherein the compound of formula I is administered in a unit dosage form of 10 mg.
8. The method of claim 1 wherein the exemestane is administered orally in a dosage range from about 5 to about 200 mg per day.
9. The method of claim 8 wherein the exemestane is administered orally in a dosage range from about 10 to 25 mg per day.
10. The method of claim 1 wherein the exemestane is admninstered parenterally from about 50 to about 500 mg per day.
11. The method of claim 10 wherein the exemestane is administered parenterally from about 100 to about 250 mg per day.
Make Better Decisions: Try a trial or see plans & pricing
Serving leading biopharmaceutical companies globally:
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.