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Claims for Patent: 8,428,709

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Claims for Patent: 8,428,709

Title:Current control for electrotransport drug delivery
Abstract: Devices, systems and methods for controlling the application of current and/or voltage to deliver drug from patient contacts of an electrotransport drug delivery device by indirectly controlling and/or monitoring the applied current without directly measuring from the cathode of the patient terminal. In particular, described herein are electrotransport drug delivery systems including constant current delivery systems having a feedback current and/or voltage control module that is isolated from the patient contacts (e.g., anodes and cathodes). The feedback module may be isolated by a transistor from the patient contacts; feedback current and/or voltage control measurements may be performed at the transistor rather than at the patient contact (e.g., cathode).
Inventor(s): White; Bradley E. (Mason, OH), Hayter; Paul (Mountain View, CA), Lemke; John (Pleasanton, CA), Satre; Scot (Brentwood, CA), Chen; Corinna X. (Oakland, CA), Read; Brian W. (Brier, WA), Dougherty; Jason E. (Seattle, WA)
Assignee: Incline Therapeutics, Inc. (Redwood City, CA) Alza Corporation (Vacaville, CA)
Application Number:13/493,314
Patent Claims: 1. An electrotransport drug delivery system having a constant current supply, the system comprising: a power source; a first patient contact connected to power source; a second patient contact connected to a current control transistor; and a sensing circuit configured to measure voltage at the transistor, wherein the sensing circuit is configured to provide feedback controlling power at the first patient contact, wherein the second patient contact is connected to the sensing circuit only through the current control transistor so that the second patient contact is electrically isolated from the sensing circuit.

2. The system of claim 1 wherein the current control transistor is controlled by an amplifier receiving input from a microcontroller.

3. The system of claim 1 wherein the sensing circuit is configured to compare the voltage applied to the transistor to a threshold voltage.

4. The system of claim 1 wherein the sensing circuit provides input to a feedback circuit.

5. The system of claim 4 wherein the feedback circuit automatically controls the power source based on the comparison between the voltage at the transistor and the threshold voltage to maintain constant current while minimizing power consumption.

6. An electrotransport drug delivery system having a constant current supply, the system comprising: a power source; a first patient contact connected to the power source; a second patient contact connected to a transistor; a current control feedback circuit for providing a control signal to the transistor when the connection between the first patient contact and the second patient contact is closed; wherein the transistor is connected to the second patient contact; and a sensing circuit configured to measure a voltage applied at the transistor when the connection is closed, wherein the sensing circuit is configured to provide feedback controlling power at the first patient contact; wherein the second patient contact is connected to the current control feedback circuit and sensing circuit only though the transistor.

7. The system of claim 6, wherein the transistor comprise a FET, and further wherein the second patient contact connected to a drain of the transistor and the control signal comprises a voltage applied to a gate of the transistor.

8. The system of claim 6, wherein the control signal provided to the transistor is controlled by an amplifier receiving input from a microcontroller.

9. The system of claim 6, wherein the feedback circuit controls the voltage applied to the power source.

10. The system of claim 6, wherein the feedback circuit compares the transistor voltage to a reference voltage.

11. The system of claim 10, wherein the feedback circuit controls the power source based on the comparison between the transistor gate voltage and the reference voltage.

12. The system of claim 6, wherein the sensing circuit is isolated from the first and second patient contacts by the transistor.

13. The system of claim 6, wherein the first patient contact is an anode and the second patient contact is a cathode.

14. The system of claim 6, wherein the feedback circuit provides a power source sufficient to deliver a constant current.

15. The system of claim 6, wherein the feedback circuit provides a power source sufficient to deliver a constant current of about 170 .mu.A.

16. The system of claim 6, wherein the connection between the first patient contact and the second patient contact is configured to be closed by a patient's skin.

17. The circuit of claim 6, wherein the transistor is located between the second patient contact and a sense resistor.

18. The system of claim 6, wherein the feedback circuit includes a digital to analogue converter for providing a constant current.

19. A method for operating an electrotransport drug delivery system including a constant current supply, the method comprising: contacting a patient's skin with an anode and cathode to form a connection between the anode and cathode; applying an anode voltage to the anode; providing a control signal to a transistor connected to the cathode; detecting a voltage at the transistor with a sensing circuit that is configured to control power at the anode, wherein the cathode is isolated from the voltage detection by the transistor; comparing the transistor voltage to a threshold voltage; and controlling the anode voltage applied to the anode based on the comparison between the transistor voltage and the threshold voltage.

20. The method of claim 19, wherein the transistor is a FET and the control signal comprises a voltage applied to a gate of the transistor.

21. The method of claim 19, wherein the anode voltage is applied to the anode in response to an input.

22. The method of claim 19, wherein the control signal applied to the transistor is provided to the transistor by an amplifier, the amplifier isolated from the anode and the cathode by the transistor.

23. The method of claim 19, wherein the current provided from the transistor is a constant current.
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