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Last Updated: April 24, 2024

Claims for Patent: 8,415,355

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Summary for Patent: 8,415,355

Title:	Pyrrolopyrimidine compounds and their uses
Abstract:	The present invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and pharmaceutical compositions thereof. The present invention also relates to use of the compounds of formula (I) in modulating the activity of protein kinases and in the treatment of disease, particularly a disease, disorder or syndrome associated with CDK 4 inhibition. ##STR00001##
Inventor(s):	Brain; Christopher Thomas (Cambridge, MA), Sung; Moo Je (Cambridge, MA), Lagu; Bharat (Acton, MA)
Assignee:	Novartis AG (Basel, CH) Astex Therapeutics Ltd. (Cambridge, GB)
Application Number:	12/545,322
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,415,355
Patent Claims:	1. A compound 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyr- imidine-6-carboxylic acid dimethylamide of the formula ##STR00253## or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising a compound according to claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 3. The composition according to claim 2 suitable for oral administration. 4. A compound 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyr- imidine-6-carboxylic acid dimethylamide of the formula ##STR00254## 5. A pharmaceutical composition comprising a compound according to claim 4 and a pharmaceutically acceptable carrier. 6. The composition according to claim 5 suitable for oral administration.

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