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Claims for Patent: 8,415,342

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Claims for Patent: 8,415,342

Title:Besifloxacin ophthalmic composition for the treatment or control of infection
Abstract: A composition comprises besifloxacin in an amount effective for treating or controlling an infection caused by an antibiotic-resistant bacterium. Such a composition can be administered to a subject for the treatment or control of bacterial conjunctivitis caused bay an antibiotic-resistant bacterium.
Inventor(s): Tyle; Praveen (Pittsford, NY), Gupta; Pramod Kumar (Pittsford, NY), Norton; Susan E. (Rochester, NY), Brunner; Lynne (Webster, NY), Blondeau; Joseph (Saskatoon, CA)
Assignee: Bausch & Lomb Incorporated (Rochester, NY)
Application Number:12/604,422
Patent Claims: 1. A method for treating or controlling bacterial conjunctivitis in a human subject, the method comprising administering to said human subject a composition comprising besifloxacin at a concentration of 0.6% (weight by volume) at a frequency of two, three, or four times per day for 5-10 days in an amount effective for said treating or controlling, wherein said bacterial conjunctivitis is caused by a bacterium selected from the group consisting of Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus warneri, Staphylococus hominis, Morganella morganii, Prevotella spp., and Fusobacterium against which an MIC.sub.90 of gatifloxacin or moxifloxacin is at least 4 .mu.g/mL.

2. The method of claim 1, wherein said bacterium is S. aureus or S. epidermidis resistant to both methicillin and ciprofloxacin.

3. A method for treating or controlling bacterial conjunctivitis in a human subject, the method comprising administering to said human subject a composition comprising besifloxacin at a concentration of 0.6% (weight by volume) at a frequency of two, three, or four times per day for 5-10 days in an amount effective for said treating or controlling, wherein said bacterial conjunctivitis is caused by a bacterium selected from the group consisting of Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus warneri, Staphylococus hominis, Staphylococcus lugdunensis, and Morganella morganii against which an MIC.sub.90 of gatifloxacin or moxifloxacin is at least 4 .mu.g/mL, and an MIC.sub.90 of ciprofloxacin is greater than 8 .mu.g/mL.
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