.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 8,410,169

« Back to Dashboard

Claims for Patent: 8,410,169

Title:Compounds and methods for delivery of prostacyclin analogs
Abstract: This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula: ##STR00001##
Inventor(s): Phares; Ken (Chapel Hill, NC), Mottola; David (Cary, NC)
Assignee: United Therapeutics Corporation (Silver Spring, MD)
Application Number:11/189,072
Patent Claims: 1. A therapeutic composition comprising a diethanolamine salt of treprostinil in combination with at least one additional cardiovascular agent selected from the group consisting of a calcium channel blocker, a phosphodiesterase inhibitor, and an endothelial antagonist.

2. A method of treating pulmonary hypertension comprising administering to a subject in need thereof an effective amount of a therapeutic composition comprising a diethanolamine salt of treprostinil in combination with at least one additional cardiovascular agent.

3. A method as claimed in claim 2, wherein the at least one additional cardiovascular agent is selected from the group consisting of a calcium channel blocker, a phosphodiesterase inhibitor, and an endothelial antagonist.

4. A composition comprising a therapeutically effective amount of treprostinil, wherein said composition is a liposome.

5. A liposome composition as claimed in claim 4, wherein the treprostinil is a diethanolamine salt of treprostinil.

6. A method of treating pulmonary hypertension comprising administering to a subject in need thereof an effective amount of the composition of claim 4.

7. A method as claimed in claim 6, wherein the treprostinil is a diethanolamine salt of treprostinil.

8. A pharmaceutical composition for oral administration comprising a therapeutically effective amount of a salt or ester of treprostinil, wherein said composition provides an oral bioavailability of treprostinil at least 50% greater than the oral bioavailability of a composition with treprostinil as a free acid.

9. The composition of claim 8, wherein said composition provides an oral bioavailability of treprostinil at least 100% greater than the oral bioavailability of a composition with treprostinil as a free acid.

10. The composition of claim 8, wherein the ester is selected from the group consisting of a benzyl ester and an amino acid ester.

11. The composition of claim 8, wherein the ester is selected from the group consisting of a benzyl ester and a diglycine ester.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc