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Last Updated: March 28, 2024

Claims for Patent: 8,410,131


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Summary for Patent: 8,410,131
Title:Cancer treatment
Abstract: Rapamycin derivatives have interesting effects in the treatment of solid tumors, optionally in combination with a chemotherapeutic agent.
Inventor(s): Lane; Heidi (Basel, CH), O'Reilly; Terence (Basel, CH), Wood; Jeanette Marjorie (Biel-Benken, CH)
Assignee: Novartis Pharmaceuticals Corporation (East Hanover, NJ)
Application Number:10/468,520
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,410,131
Patent Claims: 1. A method for inhibiting growth of solid excretory system tumors in a subject, said method consisting of administering to said subject a therapeutically effective amount of a compound of formula I ##STR00002## wherein R.sub.1 is CH.sub.3, R.sub.2 is --CH.sub.2--CH.sub.2--OH, and X is .dbd.O.

2. The method of claim 1 wherein the solid excretory system tumor is an advanced solid excretory system tumor.

3. The method of claim 1 wherein the solid excretory system tumor is a kidney tumor.

4. The method of claim 1 wherein the solid excretory system tumor is a tumor of the renal pelvis.

5. The method of claim 1 wherein the compound of formula I is administered orally.

6. The method of claim 5 wherein the compound of formula I is administered at a daily dose range of from about 0.1 to 25 mg, as a single dose or in divided doses.

7. The method of claim 5 wherein the compound of formula I is administered in a unit dosage form of from about 0.05 to 12.5 mg.

8. The method of claim 5 wherein the compound of formula I is administered in a unit dosage form of from about 0.25 to 10 mg.

9. The method of claim 8 wherein the compound of formula I is administered in a unit dosage form of 10 mg.

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