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Claims for Patent: 8,377,916

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Claims for Patent: 8,377,916

Title:Steroids as agonists for FXR
Abstract: The invention relates to compounds of formula (I): ##STR00001## wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
Inventor(s): Pellicciari; Roberto (Perugia, IT)
Assignee: Intercept Pharmaceuticals, Inc. (New York, NY)
Application Number:13/288,558
Patent Claims: 1. A method for the treatment of cholestatic liver disease, atherosclerosis, arteriosclerosis, hypercholesteremia, or hyperlipidemia comprising administering a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) ##STR00007## or a pharmaceutically acceptable salt or amino acid conjugates thereof, wherein R is ethyl and at least one pharmaceutical carrier or diluent, wherein said compound is administered at 0.01 mg/kg to 100 mg/kg per dose.

2. The method of claim 1, wherein the composition is administered orally.

3. The method of claim 1, wherein the composition is administered as a single daily dose.

4. The method of claim 1, wherein the administration is the compound of formula I ##STR00008##
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