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Last Updated: March 28, 2024

Claims for Patent: 8,377,880


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Summary for Patent: 8,377,880
Title:Therapeutic agents for reducing parathyroid hormone levels
Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X.sub.1--X.sub.2--X.sub.3--X.sub.4--X.sub.5--X.sub.6--X.sub.7, wherein the X.sub.1 subunit comprises a thiol-containing moiety and the distribution of charge on the X.sub.2--X.sub.7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.
Inventor(s): Karim; Felix (Walnut Creek, CA), Baruch; Amos (San Francisco, CA), MacLean; Derek (Los Altos, CA), Das; Kanad (San Francisco, CA), Yin; Qun (Palo Alto, CA)
Assignee: KAI Pharmaceuticals, Inc. (South San Francisco, CA)
Application Number:13/365,213
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,377,880
Patent Claims: 1. A compound comprising Ac-c(C)arrrar-NH.sub.2 (SEQ ID NO:3).

2. A pharmaceutical composition comprising a compound comprising Ac-c(C)arrrar-NH.sub.2 (SEQ ID NO:3) and a pharmaceutically acceptable excipient.

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