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|Title:||Copolymer-1 improvements in compositions of copolymers|
|Abstract:||The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.|
|Inventor(s):||Konfino; Eliezer (Ramat Gan, IL), Sela; Michael (Rehovot, IL), Teitelbaum; Dvora (Rehovot, IL), Arnon; Ruth (Rehovot, IL)|
|Assignee:||Yeda Research and Development Co. Ltd. (Rehovot, IL)|
1. A copolymer-1 composition comprising a mixture of copolymers of alanine, glutamic acid, lysine and tyrosine, in a molar ratio of approximately 6:2:5:1,
respectively, the copolymer species in the mixture being non-uniform with respect to molecular weight and sequence, which is synthesized by polymerization of suitably protected amino acid carboxyanhydrides, wherein less than 5% of the copolymers have a
molecular weight above 40 kDa, and wherein the composition is suitable for treating multiple sclerosis.
2. The copolymer-1 composition of claim 1, wherein less than 2.5% of the copolymers have a molecular weight above 40 kDa.
3. The copolymer-1 composition of claim 1, wherein the mixture of copolymers is synthesized by polymerization of N-carboxyanhydrides of alanine, tyrosine, 7-benzyl glutamate and e-N-trifluoroacetyllysine.
4. The copolymer-1 composition of claim 3, wherein less than 2.5% of the copolymers have a molecular weight above 40 kDa.