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|Title:||Carboxylic acid derivatives, their preparation and use|
|Abstract:||Carboxylic acid derivatives ##STR00001## where R--R.sup.6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.|
|Inventor(s):||Riechers; Hartmut (Neustadt, DE), Klinge; Dagmar (Heidelberg, DE), Amberg; Wilhelm (Friedrichsdorf, DE), Kling; Andreas (Mannheim, DE), Muller; Stefan (Speyer, DE), Baumann; Ernst (Dudenhofen, DE), Rheinheimer; Joachim (Ludwigshafen, DE), Vogelbacher; Uwe (Ludwigshafen, DE), Wernet; Wolfgang (Neustadt, DE), Hager-Wernet, legal representative; Andrea (Neustadt, DE), Unger; Liliane (Ludwigshafen, DE), Raschack; Manfred (Weisenheim, DE)|
|Assignee:||Abbott GmbH & Co. KG (Wiesbaden, DE)|
|Patent Claims:||1. A pharmaceutical composition comprising a compound of formula I: ##STR00016## or a pharmaceutically acceptable salt thereof, where R is a COOH group or a radical which can be hydrolyzed to COOH; R.sup.2 is a C.sub.1-C.sub.4-alkyl or C.sub.1-C.sub.4-alkoxy; X is CR.sup.14 where R.sup.14 is hydrogen or C.sub.1-C.sub.5-alkyl, or CR.sup.14 forms together with CR.sup.3 a 5- or 6-membered alkylene or alkenylene ring which can be substituted by one or two C.sub.1-C.sub.4-alkyl groups and in which in each case a methylene group can be replaced by an oxygen; R.sup.3 is a C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkoxy or CR.sub.3 is linked to CR.sub.14 as indicated above to give a 5- or 6-membered ring; R.sup.4 and R.sup.5 are each independently phenyl or naphthyl, a methylene, ethylene or ethenylene group, an oxygen or sulfur atom or an SO.sub.2, NH or N-alkyl group or a C.sub.3-C.sub.7-cycloalkyl; R.sup.6 is a hydrogen, C.sub.1-C.sub.8 alkyl, or C.sub.3-C.sub.8-cycloalkyl, where each of these radicals can be substituted with one or more substituents selected from the group consisting of: halogen, nitro, cyano, C.sub.1-C.sub.4-alkoxy, C.sub.3-C.sub.6-alkenyloxy, C.sub.3-C.sub.6-alkynyloxy, C.sub.1-C.sub.4-alkylthio, C.sub.1-C.sub.4-haloalkoxy, C.sub.1-C.sub.4-alkylcarbonyl, C.sub.1-C.sub.4-alkoxycarbonyl, C.sub.1-C.sub.8-alkylcarbonylalkyl, C.sub.1-C.sub.4-alkylamino, di-C.sub.1-C.sub.4-alkylamino, unsubstituted phenyl, and phenyl or phenoxy, wherein phenyl or phenoxy is substituted by one or more substituents selected from the group consisting of: halogen, nitro, cyano, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-haloalkyl, C.sub.1-C.sub.4-alkoxy, C.sub.1-C.sub.4-haloalkoxy and C.sub.1-C.sub.4-alkylthio; or R.sup.6 is phenyl or naphthyl, each of which can be substituted by one or more radicals selected from the group consisting of: halogen, nitro, cyano, hydroxyl, amino, C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-haloalkyl, C.sub.1-C.sub.4-alkoxy, C.sub.1-C.sub.4-haloalkoxy, phenoxy, C.sub.1-C.sub.4-alkylthio, C.sub.1-C.sub.4-alkylamino, C.sub.1-C.sub.4-dialkylamino, dioxomethylene and dioxoethylene; Y is oxygen; and Z is oxygen; and a pharmaceutically acceptable carrier.|
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