Claims for Patent: 8,338,429

Summary for Patent: 8,338,429

Title:	2-acylaminothiazole derivative or salt thereof
Abstract:	A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.
Inventor(s):	Sugasawa; Keizo (Tokyo, JP), Watanuki; Susumu (Tokyo, JP), Koga; Yuji (Tokyo, JP), Nagata; Hiroshi (Tokyo, JP), Wakayama; Ryutaro (Tokyo, JP), Hirayama; Fukushi (Tokyo, JP), Suzuki; Ken-ichi (Tokyo, JP)
Assignee:	Astellas Pharma, Inc. (Tokyo, JP)
Application Number:	12/615,968
Patent Claims:	1. A method for the treatment of idiopathic thrombocytopenia purpura in a subject in need thereof, the method comprising: administering to a subject in need thereof therapeutically effective amount of a compound selected from the group consisting of: ##STR00115## and pharmaceutically acceptable salts thereof, wherein idiopathic thrombocytopenia purpura in the subject is treated. 2. The method according to claim 1, wherein the compound is: ##STR00116## 3. The method according to claim 1 or 2, wherein the method comprises: administering the compound in a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier. 4. The method according to claim 3, wherein the pharmaceutical composition is formulated for oral administration. 5. The method according to claim 4, wherein the effective amount of the compound is a daily dosage of between about 0.01 and about 1 mg/kg. 6. The method according to claim 5, wherein the method comprises: administering the effective amount of the compound in the form of one or more tablets once daily. 7. The method according to claim 3, wherein the method comprises: administering the therapeutically effective amount of the compound to the subject having a depressed platelet level, wherein the platelet level in the subject is increased or recovered. 8. The method according to claim 1 or 2, wherein the method comprises: administering the therapeutically effective amount of the compound to the subject such that administration results in cell proliferation and production of mature megakaryocytes and platelets.