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|Title:||Topical nepafenac formulations|
|Abstract:||Topical suspension compositions of nepafenac are disclosed. The compositions are especially suitable for topical ophthalmic administration.|
|Inventor(s):||Wong; Warren (Fort Worth, TX)|
|Assignee:||Novartis AG (Basel, CH)|
|Patent Claims:||1. A topically administrable ophthalmic composition consisting of a) 0.1% (w/v) nepafenac; b) 0.5% (w/v) carbomer; c) 0.001-0.05% (w/v) tyloxapol; d) 0.3-0.5% (w/v) sodium chloride; e) 2-3% (w/v) mannitol; f) a pH-adjusting agent in an amount sufficient to cause the composition to have a pH from 7.3-7.7; g) 0.001-0.01% (w/v) benzalkonium chloride; h) 0.001-0.1% (w/v) edetate disodium; and i) water.|
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