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Generated: August 16, 2017

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Title:Pharmaceutical composition comprising cyclic somatostatin analogues
Abstract: Pharmaceutical compositions comprising a somastatin analogue in the form of a liquid formulation for parenteral administration are disclosed.
Inventor(s): Lambert; Olivier (Spechbach-le-Haut, FR), Moser; Katrin (Brookline, MA)
Assignee: Novartis AG (Basel, CH)
Application Number:12/359,527
Patent Claims: 1. A liquid formulation for parenteral administration comprising tartaric acid and a somatostatin of formula II ##STR00008## wherein the configuration at C-2 is (R) or (S) or a mixture thereof, and wherein R is NR.sub.1 R.sub.2--C.sub.2-6 alkylene or guanidine-C.sub.2-6 alkylene, and each of R.sub.1 R.sub.2 independently is H or C.sub.1-4 alkyl, in free form, salt form, or protected form.

2. The liquid formulation according to claim 1 wherein the compound of the somatostatin is in aspartate di-salt form.

3. The liquid formulation according to claim 1 wherein the formulation is adjusted to a pH of about 4 to about 4.5.

4. The liquid formulation according to claim 1 wherein the somatostatin is cyclo[{4-(NH.sub.2--C.sub.2H.sub.4--NH--CO--O)Pro}-Phg-DTrp-Lys-Tyr(4-- Bzl)-Phe] or a pharmaceutically acceptable salt thereof.

5. The liquid formulation according to claim 2 wherein the somatostatin is cyclo[{4-(NH.sub.2--C.sub.2H.sub.4--NH--CO--O)Pro}-Phg-DTrp-Lys-Tyr(4B- zl)-Phe] or a pharmaceutically acceptable salt thereof.
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Queensland Health
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Fish and Richardson

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