Claims for Patent: 8,299,209

Summary for Patent: 8,299,209

Title:	Pharmaceutical composition comprising cyclic somatostatin analogues
Abstract:	Pharmaceutical compositions comprising a somastatin analogue in the form of a liquid formulation for parenteral administration are disclosed.
Inventor(s):	Olivier Lambert, Katrin Moser
Assignee:	Recordati SA
Application Number:	US12/359,527
Patent Claims:	1. A liquid formulation for parenteral administration comprising tartaric acid and a somatostatin of formula II wherein the configuration at C-2 is (R) or (S) or a mixture thereof, and wherein R is NR1 R2—C2-6 alkylene or guanidine-C2-6 alkylene, and each of R1 R2 independently is H or C1-4 alkyl, in free form, salt form, or protected form. 2. The liquid formulation according to claim 1 wherein the compound of the somatostatin is in aspartate di-salt form. 3. The liquid formulation according to claim 1 wherein the formulation is adjusted to a pH of about 4 to about 4.5. 4. The liquid formulation according to claim 1 wherein the somatostatin is cyclo[{4-(NH2—C2H4—NH—CO—O)Pro}-Phg-DTrp-Lys-Tyr(4-Bzl)-Phe] or a pharmaceutically acceptable salt thereof. 5. The liquid formulation according to claim 2 wherein the somatostatin is cyclo[{4-(NH2—C2H4—NH—CO—O)Pro}-Phg-DTrp-Lys-Tyr(4Bzl)-Phe] or a pharmaceutically acceptable salt thereof.