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Claims for Patent: 8,299,052

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Claims for Patent: 8,299,052

Title:Pharmaceutical compositions and methods for improved bacterial eradication
Abstract: A process for treating a bacterial infection with an antibiotic, comprising: administering to a patient with a bacterial infection a product that includes a modified release dosage form containing an antibiotic, said product being administered once-a-day in a dosage and for a number of days that provides a Total T>MIC sufficient to achieve at least the minimum amount of bacterial eradication for treatment of said bacterial infection.
Inventor(s): Flanner; Henry H. (Montgomery Village, MD), Guttendorf; Robert (Gaithersburg, MD), Treacy; Donald (Woodbine, MD), Clausen; Susan P. (Ijamsville, MD), Burnside; Beth A. (Bethesda, MD)
Assignee: Shionogi Inc. (Florham Park, NJ)
Application Number:11/800,574
Patent Claims: 1. A process for treating a patient for at least one of pharyngitis or tonsillitis, caused by, or suspected to be caused by, an infection of said patient by Streptococcus pyogenes, said process for treating comprising: orally administering to said patient 775 mg of amoxicillin once a day, for ten days; wherein said amoxicillin is administered in a pharmaceutical product comprising an immediate release dosage form, a first delayed release dosage form and a second delayed release dosage form, wherein said first delayed release dosage form initiates release of amoxicillin after said immediate release dosage form initiates release of amoxicillin, and wherein said second delayed release dosage form initiates release of amoxicillin after said first delayed release dosage form initiates release of amoxicillin, whereby a Total T>MIC sufficient to achieve at least an 85% bacterial eradication rate is achieved in the patient.

2. The process of claim 1, wherein said pharmaceutical product is in tablet form.

3. The process of claim 1, wherein said pharmaceutical product is in the form of a plurality of tablets.

4. The process of claim 1, wherein said pharmaceutical product is in tablet form wherein, said immediate release dosage form comprises 45% of the tablet, wherein said first delayed release dosage form comprises 30% of the tablet, and wherein said second delayed release dosage form comprises 25% of the tablet.

5. The process of claim 1, wherein said pharmaceutical product is in capsule form.

6. The process of claim 1, wherein said pharmaceutical product is in the form of a plurality of capsules.

7. The process of claim 1, wherein said pharmaceutical product is in the form of pellets or particles suspended in a liquid.

8. The process of claim 1, wherein said pharmaceutical product is in the form of a sachet.

9. The process of claim 1, wherein said pharmaceutical product is in the form of a sprinkle.

10. The process of claim 1, wherein the Total T>MIC sufficient to achieve at least a 90% bacterial eradication rate is achieved in the patient.
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