Claims for Patent: 8,236,962

Summary for Patent: 8,236,962

Title:	Metalloenzyme inhibitor compounds
Abstract:	The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
Inventor(s):	William J. Hoekstra, Robert J. Schotzinger, Stephen W. Rafferty
Assignee:	Mycovia Pharmaceuticals Inc
Application Number:	US13/093,530
Patent Claims:	1. A compound of formula (I), or salt thereof, wherein: MBG is optionally substituted tetrazolyl, optionally substituted triazolyl, or optionally substituted pyrazolyl; R1 is halo; R2 is halo; each R3 is independently alkyl, cyano, haloalkyl, alkoxy, halo, haloalkoxy, R4 is aryl optionally substituted with O, 1, 2 or 3 independent R3; R5 is H, or —C(O)alkyl optionally substituted with amino; n is 0, 1, 2 or 3. 2. The compound of claim 1, wherein R1 is fluoro. 3. The compound of claim 1, wherein R2 is fluoro. 4. The compound of claim 1, wherein R1 and R2 are fluoro. 5. The compound of claim 1, wherein R4 is phenyl optionally substituted with 0, 1, 2 or 3 independent R3. 6. The compound of claim 1, wherein R4 is phenyl optionally substituted with 0, 1, 2 or 3 independent halo. 7. The compound of claim 1, wherein R4 is phenyl optionally substituted with 0, 1, 2 or 3 independent fluoro. 8. The compound of claim 1, wherein R4 is 2,4-difluorophenyl. 9. The compound of claim 1, wherein R5 is H. 10. The compound of claim 1, wherein R5 is amino substituted acyl. 11. The compound of claim 1, wherein: R1 is fluoro; R2 is fluoro; R4 is 2,4-difluorophenyl; and R5 is H. 12. The compound of claim 1, wherein: each R3 is independently cyano, haloalkyl, alkoxy, halo, haloalkoxy, and n is 1 or 2. 13. The compound of claim 11, wherein: each R3 is independently cyano, haloalkyl, alkoxy, halo, haloalkoxy, and n is 1. 14. The compound of claim 1, which is one of: 4-(6-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)benzonitrile (1); 2-(2, 4-Difluorophenyl)-1, 1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(trifluoromethyl)phenyl)pyridin-2-yl) propan-2-ol (2); 3-(6-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)benzonitrile (3); 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-(4-isopropoxyphenyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol (4); 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-(4-fluorophenyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol (5); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(3-(trifluoromethoxy)phenyl)pyridin-2-yl)propan-2-ol (6); 2-(2, 4-Difluorophenyl)-1, 1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(trifluoromethoxy)phenyl)pyridin-2-yl) propan-2-ol (7); 1-(5-(3-Chlorophenyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol (8); 1-(5-(4-Chlorophenyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol (9); 2-(2,4-Difluorophenyl)-1-(5-(2,5-difluorophenyl)pyridin-2-yl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol (10); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol (11); 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-(4-(2,2,3,3,3-pentafluoropropoxy)phenyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol (12); 2-(2, 4-difluorophenyl)-1, 1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2, 2, 2-trifluoroethoxy)phenyl)pyridin-2-yl) propan-2-yl 3-aminopropanoate (13); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-yl 2-aminoacetate hydrochloride (14); 2-(2,4-Difluorophenyl)-1, 1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoro methoxy)phenyl)pyridin-2-yl) propan-2-ol (15); 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-(4-fluorophenyl)pyridin-2-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (16); 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol (17); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-1-(5-(4-(trifluoromethoxy)phenyl)pyridin-2-yl) propan-2-ol (18); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-1,2,3-triazol-1-yl)-1-(5-(4-(trifluoromethoxy)phenyl)pyridin-2-yl) propan-2-ol (19); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol (20); 2-(2, 4-Difluorophenyl)-1, 1-difluoro-3-(2H-tetrazol-1-yl)-1-(5-(3-(fluorophenyl)pyridin-2-yl) propan-2-ol (21); 2-(2, 4-Difluorophenyl)-1, 1-difluoro-3-(2H-tetrazol-1-yl)-1-(5-(4-(trifluoromethylphenyl)pyridin-2-yl) propan-2-ol (22); 2-(2, 4-Difluorophenyl)-1, 1-difluoro-3-(1H-1,2,3-triazol-1-yl)-1-(5-(4-(trifluoromethylphenyl)pyridin-2-yl) propan-2-ol (23); 4-(6-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)phenol (24); 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-(3-isopropylphenyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol (25); 2-(2,4-Difluorophenyl)-1-(5-(3,4-difluorophenyl)pyridin-2-yl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol (26); 1-(5-(3-(Difluoromethoxy)phenyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol (27); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-((trifluoromethyl) thio)phenyl)pyridin-2-yl)propan-2-ol (28). 15. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.