Claims for Patent: 8,236,799

Summary for Patent: 8,236,799

Title:	Biaryl compositions and methods for modulating a kinase cascade
Abstract:	The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt thereof. The compounds of the invention are useful for methods of protecting against or treating hearing loss, osteoporosis, cell proliferative disorders, obesity, diabetes, eye disease, stroke, atherosclerosis, neuropathic pain or hepatitis B.
Inventor(s):	David G. Hangauer, Jr.
Assignee:	Atnx Spv LLC
Application Number:	US13/152,949
Patent Claims:	1. A compound according to Formula IA or a pharmaceutically acceptable salt thereof, wherein: T is a bond; Xy is N; Xz is CZ; Xa is CRa or N; Xb is CRb; Xc is CRc; Xd is CRd; Xc is CRe; Ra is hydrogen; Rb is O-lower (C1, C2, C3, C4, C5, or C6) alkyl-aryl, wherein W is H or (C1, C2, C3, C4, C5, or C6) alkyl; V is a bond or —OCH2CH2—; Rc and R5 are, independently, hydrogen, (C1, C2, C3, C4, C5, or C6) alkyl or halogen; Rd, Re and R4 are hydrogen; Z is wherein R1, R2, and R3 are, independently, hydrogen or (C1, C2, C3, C4, C5, or C6) alkyl; R7 and R11 are selected from hydrogen, (C1, C2, C3, C4, C5, or C6) alkoxy and O-benzyl; R8 and R10 are selected from hydrogen and halogen; R9 is hydrogen; n is 1; and m is 1. 2. The compound of claim 1, wherein one of R7 and R11 is (C1, C2, C3, C4, C5, or C6) alkoxy or O-benzyl and the other is hydrogen. 3. The compound of claim 2, wherein R7 or R11 is C2 alkoxy. 4. The compound of claim 2, wherein R7 or R11 is O-benzyl. 5. The compound of claim 1 according to Formula II or III: or a pharmaceutically acceptable salt thereof; wherein Rb is wherein W is hydrogen or (C1, C2, C3, C4, C5, or C6) alkyl; R4 is hydrogen; R5 is (C1, C2, C3, C4, C5, or C6) alkyl or halogen; and R8 and R10 are, independently, hydrogen or halogen. 6. The compound of claim 5 wherein the compound is a compound of formula II. 7. The compound of claim 6 wherein R5 is C1 or C2 alkyl. 8. The compound of claim 6 wherein R5 is fluoro or chloro. 9. The compound of claim 1, wherein the compound is selected from 10. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient. 11. A pharmaceutical composition comprising a compound of claim 9 or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient. 12. The compound of claim 1, wherein Rb is O-lower (C1, C2, C3, C4, C5, or C6) alkyl-aryl or 13. The compound of claim 12, wherein aryl is tetrazole. 14. The compound of claim 12, wherein V is a bond. 15. The compound of claim 1, wherein R5 is halogen. 16. The compound of claim 15, wherein halogen is fluoro.