Generated: April 26, 2017
|Title:||Benzothiazole derivative compounds, compositions and uses|
|Abstract:||This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s).|
|Inventor(s):||Klunk; William E. (Pittsburgh, PA), Mathis, Jr.; Chester A. (Pittsburgh, PA), Wang; Yanming (Imperial, PA)|
|Assignee:||University of Pittsburgh--of the Commonwealth System of Higher Education (Pittsburgh, PA)|
1. A compound of formula I ##STR00010## or a pharmaceutically acceptable salt, hydrate, solvate or prodrug of the compound, wherein: R.sup.1 is hydrogen, --OH, --NO.sub.2, --CN,
--COOR, --OCH.sub.2OR, C.sub.1-C.sub.6 alkyl, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, C.sub.1-C.sub.6 alkoxy or halo; R is C.sub.1-C.sub.6 alkyl; R.sup.2 is a radiofluoro; R.sup.3 is hydrogen, C.sub.1-C.sub.6 alkyl, C.sub.2-C.sub.6 alkenyl
or C.sub.2-C.sub.6 alkynyl; and R.sup.4 is hydrogen, C.sub.1-C.sub.6 alkyl, C.sub.2-C.sub.6 alkenyl or C.sub.2-C.sub.6 alkynyl.
2. The compound of claim 1, wherein: R.sup.1 is --OH or C.sub.1-C.sub.6 alkoxy; R.sup.2 is .sup.18F; R.sup.3 and R.sup.4 are independently selected from hydrogen and C.sub.1-C.sub.6 alkyl.
3. The compound of claim 1 having the following structure: ##STR00011##
4. A pharmaceutical composition comprising (i) an effective amount of a compound of claim 1; and (ii) a pharmaceutically acceptable carrier.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.