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Claims for Patent: 8,207,215

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Claims for Patent: 8,207,215

Title:Ketorolac tromethamine compositions for treating or preventing ocular pain
Abstract: Compositions comprising ketorolac tromethamine at a therapeutically effective concentration of less than 0.5% are disclosed herein. Methods of treating or preventing ocular pain using said compositions are also disclosed herein.
Inventor(s): Muller; Christopher A. (Foothill Ranch, CA), Cheetham; Janet K. (Laguna Niguel, CA), Kuan; Teresa H. (Placentia, CA), Power; David F. (Trabuco Canyon, CA)
Assignee: Allergan, Inc. (Irvine, CA)
Application Number:11/842,915
Patent Claims: 1. A method of controlling ocular postoperative inflammation or ocular postoperative pain comprising topically administering to said patient a composition comprising 0.4% w/v ketorolac tromethamine.

2. The method of claim 1 wherein said ocular postoperative pain is a result of photorefractive keratectomy surgery.

3. The method of claim 1 wherein said composition comprises 0.4% w/v ketorolac tromethamine, about 0.006% w/v benzalkonium chloride, about 0.015% w/v edetate disodium, about 0.003% w/v Octoxynol-40, and about 0.79% w/v sodium chloride.

4. The method of claim 3 wherein said composition comprises 0.4% w/v ketorolac tromethamine, 0.006% w/v benzalkonium chloride, 0.015% w/v edetate disodium, 0.003% w/v Octoxynol-40, 0.79% w/v sodium chloride, and an effective amount of sodium hydroxide and hydrochloric acid to adjust the pH to a range of 7.2 to 7.6.

5. The method of claim 1 wherein said composition consists of 0.4% w/v ketorolac tromethamine, 0.006% w/v benzalkonium chloride, 0.015% w/v edetate disodium, 0.003% w/v Octoxynol-40, 0.79% w/v sodium chloride, water and an effective amount of sodium hydroxide and hydrochloric acid to adjust the pH to a range of 7.2 to 7.6.

6. The method of claim 1 wherein said composition comprises 0.4% w/v ketorolac tromethamine, 0.006% w/v benzalkonium chloride, 0.015% w/v edetate disodium, 0.003% w/v Octoxynol-40, 0.79% w/v sodium chloride, and an effective amount of sodium hydroxide or hydrochloric acid to adjust the pH.

7. The method of claim 1 wherein said composition consists essentially of 0.4% w/v ketorolac tromethamine, 0.006% w/v benzalkonium chloride, 0.015% w/v edetate disodium, 0.003% w/v Octoxynol-40, 0.79% w/v sodium chloride, water and an effective amount of sodium hydroxide or hydrochloric acid to adjust the pH to a range of 7.2 to 7.6.

8. The method of claim 1 wherein said composition consists of 0.4% w/v ketorolac tromethamine, 0.006% w/v benzalkonium chloride, 0.015% w/v edetate disodium, 0.003% w/v Octoxynol-40, 0.79% w/v sodium chloride, water and an effective amount of sodium hydroxide or hydrochloric acid to adjust the pH.

9. The method of claim 1 wherein the method controls post-operative burning and stinging.

10. The method of claim 1 wherein the composition further comprises benzalkonium chloride.

11. The method of claim 1 wherein the composition further comprises about about 0.006% w/v benzalkonium chloride.

12. The method of claim 1 wherein the composition further comprises edetate disodium.

13. The method of claim 1 wherein the composition further comprises about 0.015% w/v edetate disodium.

14. The method of claim 1 wherein the composition further comprises Octoxynol-40.

15. The method of claim 1 wherein the composition further comprises about 0.003% w/v Octoxynol-40.

16. The method of claim 1 wherein the composition further comprises sodium chloride.

17. The method of claim 1 wherein the composition further comprises about 0.79% w/v sodium chloride.

18. The method of claim 1 wherein the composition has a pH of about 7.4.
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