Claims for Patent: 8,188,085

Summary for Patent: 8,188,085

Title:	Antifungal agents
Abstract:	Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-.beta.-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
Inventor(s):	Greenlee; Mark L. (Plainfield, NJ), Wilkening; Robert (Maplewood, NJ), Apgar; James (Edison, NJ), Sperbeck; Donald (East Hanover, NJ), Wildonger; Kenneth J. (Bridgewater, NJ), Meng; Dongfang (Westfield, NJ), Parker, Jr.; Dann L. (Cranford, NJ), Pacofsky; Gregory J. (Raleigh, NC), Heasley; Brian H. (Wake Forest, NC), Mamai; Ahmed (Raleigh, NC), Nelson; Kingsley (Mebane, NC)
Assignee:	Merck Sharp & Dohme Corp. (Rahway, NC) Seynexis, Inc. (Research Triangle Park, NC)
Application Number:	12/461,318
Patent Claims:	1. A compound of Formula (I): ##STR00359## or a pharmaceutically acceptable salt thereof, wherein: R.sup.1 is a group of the following structure: ##STR00360## wherein W, X', Y, and Z are independently selected from N and CR.sup.e provided that two or three of W, X', Y and Z is CR.sup.e; R.sup.e is independently selected from the group consisting of: a) H; b) Halogen; c) NR.sup.fR.sup.g; d) NHC(O)R.sup.0; e) NHC(O)NR.sup.fR.sup.g; f) NHC(O)OR.sup.0; g) NO.sub.2 h) OR.sup.0; i) SR.sup.0; j) SO.sub.2R.sup.0; k) SO.sub.2N(R.sup.0).sub.2; l) CN; m) C(O)R.sup.0; n) C(O)OR.sup.0; o) C(O)NR.sup.fR.sup.g; p) C(.dbd.NR.sup.0)N(R.sup.0).sub.2; q) C.sub.1-C.sub.6-alkyl optionally substituted with 1 to 3 substituents independently selected from phenyl, pyridyl, OR.sup.0, N(R.sup.0).sub.2, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2 or halogen; r) C.sub.2-C.sub.6-alkenyl optionally substituted with 1 to 3 substituents independently selected from phenyl, OR.sup.0, N(R.sup.0).sub.2, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2 or halogen; s) C.sub.3-C.sub.6-cycloalkyl, optionally substituted with oxo, OR.sup.0, N(R.sup.0).sub.2, CO.sub.2R.sup.0 or C(O)N(R.sup.0).sub.2; t) heterocyclyl, wherein the heterocyclyl is a 4- to 6-membered saturated or unsaturated non-aromatic ring having 1, 2 or 3 heteroatoms selected from N, O or S, attached through a carbon or nitrogen on the ring, and optionally substituted on a ring carbon with 1 to 2 substituents independently selected from N(R.sup.0).sub.2, imino, oxo, OR.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2 and C.sub.1-C.sub.6-alkyl unsubstituted or substituted with 1 to 3 substituents independently selected from N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2 and halogen; the heterocyclyl may also be optionally substituted on a ring nitrogen atom that is not the point of attachment with C(O)R.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2, SO.sub.2R.sup.0 or C.sub.1-C.sub.6 alkyl unsubstituted or substituted with 1 to 3 substituents independently selected from N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2 and halogen; the heterocyclyl may also be optionally substituted on a sulfur atom with 1 or 2 oxo groups; u) aryl, wherein aryl is phenyl or napthyl and aryl is unsubstituted or substituted with 1 or 2 substituents independently selected from halogen, N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, CN, C(O)N(R.sup.0).sub.2, C(.dbd.NR.sup.0)N(R.sup.0).sub.2, heterocyclyl as defined above, phenyl, pyridyl, and C.sub.1-C.sub.6-alkyl wherein said alkyl is optionally substituted with 1 to 3 substituents independently selected from N(R.sup.0).sub.2, OR.sup.0, or halogen; v) heteroaryl, wherein heteroaryl is a 5- or 6-membered monocyclic aromatic ring or 9- or 10-membered bicyclic aromatic ring having 1, 2 or 3 heteroatoms selected from N, O or S, attached through a ring carbon or nitrogen, and optionally substituted on a ring carbon that is not the point of attachment, with 1 or 2 substituents independently selected from halogen, CF.sub.3, NR.sup.fR.sup.g, NHC(O)R.sup.0, OR.sup.0, CO.sub.2R.sup.0, CON(R.sup.0).sub.2, C(.dbd.NR.sup.0)N(R.sup.0).sub.2, CN, heterocyclyl as defined above, phenyl, pyridyl, and C.sub.1-C.sub.6 alkyl unsubstituted or substituted with 1 or 2 substituents independently selected from N(R.sup.0).sub.2 and OR.sup.0; the heteroaryl may also be optionally substituted on a ring nitrogen atom that is not the point of attachment with O or C.sub.1-C.sub.6 alkyl; R.sup.f is H, C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.6-cycloalkyl or phenyl; R.sup.g is H or C.sub.1-C.sub.6-alkyl optionally substituted with 1 to 3 substituents independently selected from phenyl, OR.sup.0, N(R.sup.0).sub.2 or halogen; R.sup.f and R.sup.g are optionally taken together with the attached nitrogen atom to form a 3- to 7-membered ring having 0-1 additional heteroatoms independently selected from N, O and S wherein said ring may be optionally substituted on a ring nitrogen atom that is not the point of attachment with C(O)R.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2, SO.sub.2R.sup.0, or C.sub.1-C.sub.6 alkyl unsubstituted or substituted with 1 or 2 substituents independently selected from N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2 or halogen; said ring may also be optionally substituted on a sulfur atom with 1 or 2 oxo groups; R.sup.2 is a group of the following structure: ##STR00361## m is 0 or 1; n is 0 or 1; p is 0 or 1; T is NR.sup.6R.sup.7 or OR.sup.10; R.sup.5 is H or C.sub.1-C.sub.6-alkyl, unsubstituted or substituted with 1 or 2 substituents independently selected from N(R.sup.0).sub.2 and OR.sup.0; R.sup.6 is H, C.sub.1-C.sub.6-alkyl or C.sub.3-C.sub.6 cycloalkyl; R.sup.7 is a) H; b) C.sub.1-C.sub.6-alkyl, unsubstituted or substituted with 1 or 2 substituents independently selected from N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, OC(O)R.sup.0, NHC(O)R.sup.0, C(O)N(R.sup.0).sub.2, phenyl, heteroaryl, and heterocyclyl, wherein heteroaryl and heterocyclyl are as defined above in the definition of R.sup.e; c) C.sub.3-C.sub.6-cycloalkyl; d) C(O)R.sup.0; e) C(O)OC.sub.1-C.sub.6-alkyl; f) C(O)NHR.sup.0; g) C(.dbd.NH)R.sup.0; h) C(.dbd.NR.sup.0)NHR.sup.0; R.sup.6 and R.sup.7 are optionally taken together with the attached nitrogen atom to form a 4- to 7-membered saturated, unsaturated or aromatic ring having 0 or 1 additional heteroatoms independently selected from N, O and S, wherein said ring is optionally substituted on a ring carbon with 1 to 2 substituents independently selected from halogen, CF.sub.3, N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2, and C.sub.1-C.sub.6 alkyl unsubstituted or substituted with 1 or 2 substituents independently selected from OR.sup.0 and N(R.sup.0).sub.2; said ring may also be optionally substituted on a ring nitrogen atom that is not the point of attachment with C(O)R.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2, SO.sub.2R.sup.0 or C.sub.1-C.sub.6 alkyl unsubstituted or substituted with 1 to 3 substituents independently selected from N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2 and halogen; said ring may also be optionally substituted on a sulfur atom with 1 or 2 oxo groups; R.sup.6 and R.sup.8 are optionally taken together to form, with the intervening atoms, a 4- to 7-membered saturated ring having 0 or 1 additional heteroatoms independently selected from N, O and S wherein said ring is optionally substituted as defined above for R.sup.6 and R.sup.7 when joined together to form a ring; R.sup.6 and R.sup.5 are optionally taken together to form, with the intervening atoms, a 4- to 7-membered saturated ring having 0 or 1 additional heteroatoms independently selected from N, O and S wherein said ring is optionally substituted as defined above for R.sup.6 and R.sup.7 when joined together to form a ring; R.sup.8 is selected from the group consisting of a) hydrogen, b) C.sub.1-C.sub.6-alkyl, unsubstituted or substituted with F, OR.sup.0, N(R.sup.0).sub.2 or SO.sub.2R.sup.0, c) C.sub.3-C.sub.6-cycloalkyl, d) C.sub.4-C.sub.7-cycloalkyl-alkyl, e) aryl, wherein aryl is phenyl or naphthyl and said aryl is unsubstituted or substituted with 1 to 3 substituents selected from C.sub.1-C.sub.6-alkyl, halogen, OCF.sub.3, CF.sub.3, N(R.sup.0).sub.2 and OR.sup.0, and f) heteroaryl, wherein heteroaryl is as defined above in the definition of R.sup.e; R.sup.9 is C.sub.1-C.sub.6-alkyl, unsubstituted or substituted with OR.sup.0 or SO.sub.2R.sup.0; R.sup.8 and R.sup.9 are optionally taken together to form a 3- to 7-membered saturated ring having 0 or 1 additional heteroatoms independently selected from N, O, and S, wherein said ring is optionally substituted as defined above for R.sup.6 and R.sup.7 when joined to form a ring; R.sup.10 is selected from the group consisting of a) H, b) C.sub.1-C.sub.6-alkyl, unsubstituted or substituted with 1 or 2 substituents selected from N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, OC(O)R.sup.0, NHC(O)R.sup.0, C(O)N(R.sup.0).sub.2, phenyl, heteroaryl, and heterocyclyl, wherein heteroaryl and heterocyclyl are as defined above in the definition of R.sup.e, c) C.sub.3-C.sub.6-cycloalkyl, d) C(O)R.sup.0, e) C(O)NHR.sup.0, R.sup.3 is C(O)R.sup.14; R.sup.14 is OH, OR.sup.15 or N(R.sup.0).sub.2; R.sup.15 is C.sub.1-C.sub.6-alkyl, unsubstituted or substituted with 1 or 2 substituents independently selected from phenyl and OC(O)R.sup.0, wherein said phenyl is optionally substituted with 1 to 3 OR.sup.0 groups; X is O or H, H; each R.sup.0 is independently H, C.sub.1-C.sub.6 alkyl, C.sub.3-C.sub.6 cycloalkyl or benzyl. 2. The compound according to claim 1, wherein R.sup.3 is C(O)OH. 3. The compound according to claim 2, wherein the compound is of Formula Ia, or a pharmaceutically acceptable salt thereof: ##STR00362## 4. The compound according to claim 1, wherein X is H, H. 5. The compound according to claim 1, wherein X is O. 6. The compound according to claim 1, wherein T is OR.sup.10. 7. The compound according to claim 1, wherein T is NR.sup.6R.sup.7. 8. The compound according to claim 7, wherein R.sup.2 is ##STR00363## 9. The compound according to claim 7, wherein R.sup.2 is ##STR00364## 10. The compound according to claim 9, wherein R.sup.2 is ##STR00365## 11. The compound according to claim 7, wherein R.sup.2 is ##STR00366## 12. The compound according to claim 7, wherein R.sup.2 is ##STR00367## 13. The compound according to claim 12, wherein R.sup.2 is ##STR00368## 14. The compound according to claim 7, wherein R.sup.2 is ##STR00369## and wherein R.sup.6 is H or C.sub.1-C.sub.3-alkyl; R.sup.7 is H or methyl; R.sup.8 is C.sub.1-C.sub.5-alkyl, C.sub.3-C.sub.5 cycloalkyl or C.sub.4-C.sub.6 cycloalkyl-alkyl; R.sup.9 is H or C.sub.1-C.sub.3-alkyl; or R.sup.8 and R.sup.9 are optionally taken together to form a 5- to 6-membered saturated ring having 0-1 heteroatom selected from O or S. 15. The compound according to claim 7, wherein R.sup.2 is ##STR00370## wherein R.sup.6 is H, methyl, ethyl or n-propyl; R.sup.8 is ethyl, i-propyl, t-butyl or 1-methylcyclopropyl; R.sup.9 is methyl or ethyl; or R.sup.8 and R.sup.9 are optionally taken together to form a 6-membered saturated ring containing 0 or 1 oxygen atoms. 16. The compound according to claim 1, wherein R.sup.2 is selected from the group consisting of: ##STR00371## 17. The compound of according to claim 1, wherein R.sup.1 is ##STR00372## wherein W, X', Y, and Z are independently selected from N and CR.sup.e provided that two of W, X', Y and Z are CR.sup.e. 18. The compound according to claim 17, wherein R.sup.1 is ##STR00373## 19. The compound according to claim 17, wherein R.sup.1 is ##STR00374## 20. The compound according to claim 17, wherein R.sup.1 is ##STR00375## wherein R.sup.e is NR.sup.fR.sup.g. 21. The compound according to claim 17, wherein R.sup.1 is ##STR00376## wherein R.sup.e is selected from the following: a) H, b) Halogen, c) C(O)NR.sup.fR.sup.g, d) heterocyclyl, wherein the heterocyclyl is a 4- to 6-membered saturated or unsaturated non-aromatic ring having 1 or 2 heteroatoms selected from N, O or S, attached through a carbon or nitrogen on the ring and optionally substituted on a ring carbon with N(R.sup.0).sub.2, OR.sup.0, imino or oxo; the heterocyclyl may also be optionally substituted on a ring nitrogen atom that is not the point of attachment with C(O)R.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2 or C.sub.1-C.sub.4 alkyl, e) aryl, wherein aryl is phenyl or napthyl and aryl is unsubstituted or substituted with 1 or 2 substituents independently selected from halogen, CF.sub.3, N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, CN, C(O)N(R.sup.0).sub.2, C(.dbd.NR.sup.0)N(R.sup.0).sub.2, and C.sub.1-C.sub.3-alkyl wherein said alkyl is optionally substituted with N(R.sup.0).sub.2 or OR.sup.0; and f) heteroaryl, wherein heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O or S, attached through a ring carbon or nitrogen, and optionally substituted on a ring carbon that is not the point of attachment, with 1 or 2 substituents independently selected from halogen, CF.sub.3, NR.sup.fR.sup.g, NHC(O)R.sup.0, OR.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2, C(.dbd.NR.sup.0)N(R.sup.0).sub.2, CN and C.sub.1-C.sub.3 alkyl, wherein said alkyl is optionally substituted with N(R.sup.0).sub.2 or OR.sup.0; the heteroaryl may also be optionally substituted on a nitrogen atom that is not the point of attachment with O or C.sub.1-C.sub.3 alkyl. 22. The compound according to claim 17, wherein R.sup.1 is ##STR00377## wherein R.sup.e is C(O)NR.sup.fR.sup.g. 23. The compound according to claim 22, wherein R.sup.1 is selected from the group consisting of: ##STR00378## 24. The compound according to claim 17, wherein R.sup.1 is ##STR00379## wherein R.sup.e is heterocyclyl, wherein the heterocyclyl is a 4- to 6-membered saturated or unsaturated non-aromatic ring having 1 or 2 heteroatoms selected from N, O or S, attached through a carbon or nitrogen on the ring and optionally substituted on a ring carbon with N(R.sup.0).sub.2, OR.sup.0, imino or oxo; the heterocyclyl may also be optionally substituted on a ring nitrogen atom that is not the point of attachment with C(O)R.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2 or C.sub.1-C.sub.4 alkyl. 25. The compound according to claim 24, wherein R.sup.1 is selected from the group consisting of: ##STR00380## 26. The compound according to claim 17, wherein R.sup.1 is ##STR00381## wherein R.sup.e is aryl, wherein aryl is phenyl or napthyl and aryl is unsubstituted or substituted with 1 or 2 substituents independently selected from halogen, CF.sub.3, N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, CN, C(O)N(R.sup.0).sub.2, C(.dbd.NR.sup.0)N(R.sup.0).sub.2, and C.sub.1-C.sub.3-alkyl wherein said alkyl is optionally substituted with N(R.sup.0).sub.2 or OR.sup.0. 27. The compound according to claim 26, wherein R.sup.1 is selected from the group consisting of: ##STR00382## 28. The compound according to claim 17, wherein R.sup.1 is ##STR00383## wherein R.sup.e is heteroaryl, wherein heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O or S, attached through a ring carbon or nitrogen, and optionally substituted on a ring carbon that is not the point of attachment, with halogen, NR.sup.fR.sup.g, NHC(O)R.sup.0, OR.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2, C(.dbd.NR.sup.0)N(R.sup.0).sub.2, CN or C.sub.1-C.sub.3 alkyl, wherein said alkyl is optionally substituted with N(R.sup.0).sub.2 or OR.sup.0; the heteroaryl may also be optionally substituted on a nitrogen atom that is not the point of attachment with O or C.sub.1-C.sub.3 alkyl. 29. The compound according to claim 28, wherein R.sup.1 is selected from the group consisting of: ##STR00384## 30. The compound of according to claim 1, wherein R.sup.1 is ##STR00385## wherein W, X', Y, and Z are independently selected from N and CR.sup.e provided that three of W, X', Y and Z are CR.sup.e. 31. The compound according to claim 30, wherein R.sup.1 is ##STR00386## 32. The compound according to claim 30, wherein R.sup.1 is ##STR00387## 33. The compound according to claim 30, wherein R.sup.1 is ##STR00388## wherein R.sup.e is selected from the group consisting of: a) H; b) C(O)NR.sup.fR.sup.g; c) aryl, wherein aryl is phenyl or napthyl and aryl is unsubstituted or substituted with 1 or 2 substituents independently selected from halogen, CF.sub.3, N(R.sup.0).sub.2, OR.sup.0, CO.sub.2R.sup.0, CN, C(O)N(R.sup.0).sub.2, C(.dbd.NR.sup.0)N(R.sup.0).sub.2, and C.sub.1-C.sub.3-alkyl wherein said alkyl is optionally substituted with N(R.sup.0).sub.2 or OR.sup.0; and d) heteroaryl, wherein heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O or S, attached through a ring carbon or nitrogen, and optionally substituted on a ring carbon that is not the point of attachment, with halogen, NR.sup.fR.sup.g, NHC(O)R.sup.0, OR.sup.0, CO.sub.2R.sup.0, C(O)N(R.sup.0).sub.2, C(.dbd.NR.sup.0)N(R.sup.0).sub.2, CN or C.sub.1-C.sub.3 alkyl, wherein said alkyl is optionally substituted with N(R.sup.0).sub.2 or OR.sup.0; the heteroaryl may also be optionally substituted on a nitrogen atom that is not the point of attachment with O or C.sub.1-C.sub.3 alkyl. 34. The compound according to claim 1 having Formula (II): ##STR00389## or a pharmaceutically acceptable salt thereof, wherein: X is O or H, H; R.sup.e is C(O)NR.sup.fR.sup.g or a 6-membered ring heteroaryl group containing 1 or 2 nitrogen atoms wherein the heteroaryl group is optionally mono-substituted on a ring carbon with fluoro or chloro or on a ring nitrogen with oxygen; R.sup.fR.sup.g, R.sup.6 and R.sup.7 are each independently hydrogen or C.sub.1-C.sub.3 alkyl; R.sup.8 is C.sub.1-C.sub.4 alkyl, C.sub.3-C.sub.4 cycloalkyl or C.sub.4-C.sub.5 cycloalkyl-alkyl; R.sup.9 is methyl or ethyl; R.sup.8 and R.sup.9 are optionally taken together to form a 6-membered saturated ring containing 1 oxygen atom. 35. The compound according to claim 34, wherein X is H, H. 36. The compound according to claim 34 wherein R.sup.e is pyridyl or pyrimidinyl optionally mono-substituted on a ring carbon with fluoro or chloro or on a ring nitrogen with oxygen. 37. The compound according to claim 34, wherein R.sup.e is 4-pyridyl. 38. The compound according to claim 34, wherein R.sup.e is C(O)NH.sub.2 or C(O)NH(C.sub.1-C.sub.3 alkyl). 39. The compound according to claim 34, wherein R.sup.8 is C.sub.1-C.sub.4 alkyl and R.sup.9 is methyl. 40. The compound according to claim 34, wherein R.sup.8 is isopropyl or t-butyl, and R.sup.9 is methyl. 41. The compound according to claim 34, wherein R.sup.6 and R.sup.7 are independently hydrogen or methyl. 42. The compound according to claim 1, wherein the compound is selected from the group consisting of: (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(1H-1,2,4-triazol-1-yl)-1,6,6a- ,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-pro- pano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(4H-1,2,4-triazol-4-yl)-1,6,6a- ,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-pro- pano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(1H-1,2,4-triazol-1-yl)-1,6,6a,7,- 8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propan- o-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2S)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(1H-1,2,4-triazol-1-yl)-1- ,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4- a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2S)-2-(dimethylamino)-2,3- -dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(1H-1,2,4-triazol-1-yl)- -1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1- ,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(3-amino-1H-1,2,4-triazol-1-- yl)-15-[[(2R)-2,3-dimethyl-2-(methylamino)butyl]oxy]-8-[(1R)-1,2-dimethylp- ropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(3-bromo-4H-1,2,4-triazol-4-yl)-8-[(1R)-1,2-dimethylpropyl]-1- ,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4- a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(5-bromo-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylpropyl]-1- ,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4- a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(3-bromo-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylpropyl]-1- ,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4- a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]14-(3-cyano-4H-1,2,4-triazol-4-yl)-8-[(1R)-1,2-dimethylpropyl]-1,- 6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a- -propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]14-(5-cyano-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylpropyl]-1,- 6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a- -propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1 S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylbut- yl]oxy]14-(3-cyano-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylpropyl]1,6,6- a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-pr- opano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[3-(methoxycarbonyl)-1H-1,2,4-tri- azol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(methoxycarbonyl)-1H-1,2,4-tri- azol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(3-chloro-4H-1,2,4-triazol-4- -yl)-15-[2-(dimethylamino)-2,3-dimethylbutoxy]-8-[(1R)-1,2-dimethylpropyl]- -1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-6-ox- o-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(5-chloro-1H-1,2,4-triazol-1- -yl)-15-[2-(dimethylamino)-2,3-dimethylbutoxy]-8-[(1R)-1,2-dimethylpropyl]- -1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-6-ox- o-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(3-chloro-1H-1,2,4-triazol-1- -yl)-15-[2-(dimethylamino)-2,3-dimethylbutoxy]-8-[(1R)-1,2-dimethylpropyl]- -1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-6-ox- o-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-14-(5-chloro-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylpropy- l]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H- -1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-14-(5-bromo-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylpropyl- ]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-- 1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[tetrahydro-4-(methylamino)-2H-pyran-4-yl]methoxy]-14-(1H-1,2,4-triazol-1- -yl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-- 4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(5-bromo-1H-1,2,4-triazol-1-- yl)-8-[(1R)-1,2-dimethylpropyl]-15-[[tetrahydro-4-(methylamino)-2H-pyran-4- -yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetr- amethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(5-chloro-1H-1,2,4-triazol-1- -yl)-8-[(1R)-1,2-dimethylpropyl]-15-[[tetrahydro-4-(methylamino)-2H-pyran-- 4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tet- ramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H-pyran- -4-yl)methoxy]-14-(5-bromo-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylprop- yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4- H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[1-(methylamino)cyclohexyl]methoxy]-14-(1H-1,2,4-triazol-1-yl)-1,6,6a,7,8- ,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano- -2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(1H-1,2,4-triazol-1-yl)-1- ,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4- a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-(dimethylamino)-2,3- -dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(1H-1,2,4-triazol-1-yl)- -1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1- ,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(5-chloro-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylpropyl]-- 1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,- 4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(5-chloro-1H-1,2,4-triazol-1- -yl)-15-[[(2R)-2,3-dimethyl-2-(methylamino)butyl]oxy]-8-[(1R)-1,2-dimethyl- propyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrameth- yl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(5-bromo-1H-1,2,4-triazol-1-- yl)-15-[[(2R)-2,3-dimethyl-2-(methylamino)butyl]oxy]-8-[(1R)-1,2-dimethylp- ropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4-a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-iodo-1H-1,2,4-triazol-- 1-yl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl- -4H-1,4-a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(phenylmethoxy)carbon- yl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1- ,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyl- ic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-3,3-d- imethylbutyl]oxy]-14-(3-amino-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylp- ropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(3-amino-1H-1,2,4-triazol-1-- yl)-15-[[(2S)-2,3-dimethyl-2-(methylamino)butyl]oxy]-8-[(1R)-1,2-dimethylp- ropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(3-amino-1H-1,2,4-triazol-1-- yl)-15-[[(2S)-3,3-dimethyl-2-(methylamino)butyl]oxy]-8-[(1R)-1,2-dimethylp- ropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(3-amino-1H-1,2,4-triazol-1-- yl)-15-[[(2S)-2-(dimethylamino)-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethy- lpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(3-amino-1H-1,2,4-triazol-1-- yl)-15-[[(2R)-2-(dimethylamino)-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethy- lpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(5-bromo-3-nitro-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylp- ropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(3-bromo-5-nitro-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylp- ropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(3-amino-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylpropyl]-1- ,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4- a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15)-15-[[(2R)-2-amino-2,3-dimethylbu- tyl]oxy]-14-(5-amino-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylpropyl]-1,- 6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a- -propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(3-amino-5-cyclopropyl-1H-1,- 2,4-triazol-1-yl)-15-[[(2R)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dim- ethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetr- amethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(5-amino-3-cyclopropyl-1H-1,- 2,4-triazol-1-yl)-15-[[(2R)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dim- ethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetr- amethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(3,5-dibromo-4H-1,2,4-triazol-4-yl)-8-[(1R)-1,2-dimethylpropy- l]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H- -1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(3,5-dibromo-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylpropy- l]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H- -1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(3,5-dichloro-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethylprop- yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4- H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[3-amino-5-(hydroxymethyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2- -dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(3-amino-5-phenyl-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-dimethyl- propyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrameth- yl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[3-[[(1-methylethyl)amino]carbony- l]-4H-1,2,4-triazol-4-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,- 6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyli- c acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-di- methylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[3-[[(1-methylethyl)amino]- carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecah- ydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-ca- rboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(1-methylethyl)amino]carbony- l]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,- 6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyli- c acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2- -(methylamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(1-methylethy- l)amino]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a- -dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]py- ran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(1-methylethyl)amino- ]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodeca- hydro-1,6a,8,10a-tetramethyl-6-oxo-4H-1,4a-propano-2H-phenanthro[1,2-c]pyr- an-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(methylamino)carbonyl- ]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6- a,8,10a-tetramethyl-6-oxo-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carb- oxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-15-[[(2R)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethy- lpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-15-[[(2R)-2-(dimethylamino)-2,3-dimethylbutyl]oxy]-8-[(1R)-1- ,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[(2R)-2-(ethylamino)-2,3-dim- ethylbutyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-t- etramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dime- thylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-[(methylamino)carbonyl]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3,3-trimethy- l-2-(methylamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-- 1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[(tetrahydro-4-(met- hylamino)-2H-pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecah- ydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-ca- rboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[(2R)-2,3-dimethyl-2-(methyl- amino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[(2R)-2,3-dimethyl-2-(propyl- amino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(methylamino)carbonyl]-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-[(dimethylamino)carbonyl]-1H-1,2,4-triazol-1-yl]-8-[(1R)-1- ,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(methylamino)carbonyl- ]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6- a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-(dimethylamin- o)-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(methylamino)- carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecah- ydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-ca- rboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[(2R)-2,3-dimethyl-2-(propylamino)butyl]oxy]-14-[5-[(methylamino)carbonyl- ]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6- a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[(dimethylamino)car- bonyl]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3-dimethyl-2-(methylamino)butyl]- oxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecah- ydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-ca- rboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[(dimethylamino)carbonyl]- -1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[(2R)-2-(ethylamin- o)-2,3-dimethylbutyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,- 6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyli- c acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-di- methylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(ethylamino)carbonyl]-- 1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-- (methylamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(ethylamino)car- bonyl]1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbox- ylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3- -dimethylbutyl]oxy]-14-[5-[(diethylamino)carbonyl]-1H-1,2,4-triazol-1-yl]-- 8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-- dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(propylamino)carbony- l]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,- 6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyli- c acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-(dimethylami- no)-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(1-methylet- hyl)amino]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,1- 2a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]- pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[(2R)-2-(ethylamino)-2,3-dimethylbutyl]oxy]-14-[5-[[(1-methylethyl)amino]- carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecah- ydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-ca- rboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[(2R)-2,3-dimethyl-2-(propylamino)butyl]oxy]-14-[5-[[(1-methylethyl)amino- ]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodeca- hydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-c- arboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-[(cyclopropylamino)carbonyl]-1H-1,2,4-triazol-1-yl]-8-[(1R- )-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8- ,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[(cyclopropylamino)- carbonyl]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3-dimethyl-2-(methylamino)but- yl]oxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dode- cahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7- -carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[(cyclopropylamino)carbon- yl]-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[(2R)-2-(ethyla- mino)-2,3-dimethylbutyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4-a-propano-2H-phenanthro[1,2-c]pyran-7-carbo- xylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-[(butylamino)carbonyl]-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-- dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-t- etramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(2-methylpropyl)amino]carbon- yl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1- ,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyl- ic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-d- imethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[[(1S)-1-methylpropyl- ]amino]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-- dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4-a-propano-2H-phenanthro[1,2-c]py- ran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[[(1R)-1-methylpropyl]amino]c- arbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahy- dro-1,6a,8,10a-tetramethyl-4H-1,4-a-propano-2H-phenanthro[1,2-c]pyran-7-ca- rboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-[[(1,1-dimethylethyl)amino]carbonyl]-1H-1,2,4-triazol-1-yl- ]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydr- o-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbo- xylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-[(cyclobutylamino)carbonyl]-1H-1,2,4-triazol-1-yl]-8-[(1R)- -1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,- 10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dim- ethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(2,2-dimethylpropyl)am- ino]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dod- ecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-- 7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(phenylamino)carbonyl]-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(phenylmethyl)amino]carbonyl- ]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6- a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dim- ethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(2-phenylethyl)amino]c- arbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahy- dro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-car- boxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(2-fluoroethyl)amino]carbony- l]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,- 6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyli- c acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2- -(methylamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(2-fluoroethy- l)amino]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a- -dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]py- ran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[(2R)-2-(ethylamino)-2,3-dimethylbutyl]oxy]-14-[5-[[(2-fluoroethyl)amino]- carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecah- ydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-ca- rboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-[[(2,2-difluoroethylamino]carbonyl]-1H-1,2,4-triazol-1-yl]- -8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbox- ylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3- -dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(2,2,2-trifluoroet- hyl)amino]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,1- 2a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]- pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(2-methoxyethyl)amino]carbon- yl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1- ,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyl- ic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-d- imethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(2-ethoxyethyl)amino- ]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodeca- hydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-c- arboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-[[[2-(dimethylamino)ethyl]amino]carbonyl]-1H-1,2,4-triazol- -1-yl]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodec- ahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-- carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(1-azetidinylcarbonyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-- dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-t- etramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-pyrrolidinylcarbonyl)-1H-1,- 2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a- -tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-morpholinylcarbonyl)-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(4-methyl-1-piperazinyl)carbo- nyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-- 1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[(2R)-2,3,3-trimeth- yl-2-(methylamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbox- ylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3- ,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(methylamino)car- bonyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-14-[5-[(dimethylamino)carbonyl]-1H-1,2,4-triazol-1-yl]-8-[(1R- )-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8- ,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(ethylamino)carbonyl- ]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6- a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(2-fluoroethyl)amin- o]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodec- ahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-- carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(1-methylethyl)amino]carb- onyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbox- ylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylp- ropyl]-14-[5-[[(1-methylethyl)amino]carbonyl]-1H-1,2,4-triazol-1-yl]-15-[[- (2R)-2,3,3-trimethyl-2-(methylamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,- 12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,- 2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[(2R)-2-[(2-hydroxyethyl)amino]-2,3,3-trimethylbutyl]oxy]-14-[5-[(methyla- mino)carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-do- decahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran- -7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[[(2-aminoethyl)amino]car- bonyl]-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[(2R)-2,3,3-- trimethyl-2-(methylamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dode- cahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7- -carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-15-[[(2R)-2-amino-3,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethy- lpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-3,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(methylamino)carbonyl]-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-3,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(1-methylethyl)amino]carbony- l]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,- 6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyli- c acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H- -1,2,4-triazol-1-yl]-15-(2-amino-2-ethylbutoxy)-8-[(1R)-1,2-dimethylpropyl- ]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-- 1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-(2-amino-2-ethylbutoxy)-8-[(- 1R)-1,2-dimethylpropyl]-14-[5-[(methylamino)carbonyl]-1H-1,2,4-triazol-1-y- l]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H- -1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-(2-amino-2-ethylbutoxy)-8-[(- 1R)-1,2-dimethylpropyl]-14-[5-[[(1-methylethyl)amino]carbonyl]-1H-1,2,4-tr- iazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-15-[[(2S)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethy- lpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2S)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(methylamino)carbonyl]-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2S)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(propylamino)carbonyl]-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-15-[(1-aminocyclohexyl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-- 1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,- 4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[1-(methylamino)cyclohexyl]m- ethoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrameth- yl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(1-aminocyclohexyl)methoxy]- -8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(1-methylethyl)amino]carbonyl]-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[1-(ethylamino)cyclohexyl]me- thoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-15-[[1-(propylamino)cyclohexyl]m- ethoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrameth- yl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-15-[(4-aminotetrahydro-2H-pyran-4-yl)methoxy]-8-[(1R)-1,2-di- methylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tet- ramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H-pyran- -4-yl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(methylamino)carbonyl]-1- H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8- ,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropy- l]-14-[5-[(methylamino)carbonyl]-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-- (methylamino)-2H-pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dod- ecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-- 7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H-pyran- -4-yl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(methylamino)carbonyl]-1- H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8- ,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropy- l]-14-[5-[[(1-methylethyl)amino]carbonyl]-1H-1,2,4-triazol-1-yl]-15-[[tetr- ahydro-4-(methylamino)-2H-pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,1- 2,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4-a-propano-2H-phenanthro[1,- 2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-[(methylamino)carbonyl]-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methy- lamino)-2H-thiopyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodec- ahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-- carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-[(methylamino)carbonyl]-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methy- lamino)-1,1-dioxido-2H-thiopyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,- 12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,- 2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[3-(aminocarbonyl)-5-bromo-1- H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2- -dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-3-bromo-1- H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2- -dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[3-amino-5-(aminocarbonyl)-1- H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2- -dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4R,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylbu- tyl]oxy]-14-[3-bromo-5-(methoxycarbonyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,- 2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a- -tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-3-bromo-1- H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-- 1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,1- 0a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dim- ethylbutyl]oxy]-14-[3-amino-5-[(methylamino)carbonyl]-1H-1,2,4-triazol-1-y- l]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahyd- ro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carb- oxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[3-(aminosulfonyl)-4H-1,2,4-- triazol-4-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dime- thylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[3-(aminosulfonyl)-1H-1,2,4-- triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dime- thylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminosulfonyl)-1H-1,2,4-- triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dime- thylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-(2-amino-2-ethylbutoxy)-14-[- 5-(aminosulfonyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-1,6,6- a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-pr- opano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-(2-amino-2-ethylbutoxy)-8-[(- 1R)-1,2-dimethylpropyl]-14-[5-[(ethylamino)sulfonyl]-1H-1,2,4-triazol-1-yl- ]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-- 1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-(2-amino-2-ethylbutoxy)-8-[(- 1R)-1,2-dimethylpropyl]-14-[5-[(propylamino)sulfonyl]-1H-1,2,4-triazol-1-y- l]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H- -1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(aminosulfonyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dimethy- lpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(4,5-dihydro-1H-imidazol-2-yl)-1H-1,2,4-triazol-1-yl]-8-[(- 1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a- ,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dim- ethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1,4,5,6-tetrahydro-2-py- rimidinyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodeca- hydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-c- arboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)-1H-1,2,4-triazol-1- -yl]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecah- ydro-1,6a,8,10a-tetramethyl-4H-1,4-a-propano-2H-phenanthro[1,2-c]pyran-7-c- arboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-ethyl-4,5-dihydro-1H-imidaz- ol-2-yl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahy- dro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-car- boxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-[4,5-dihydro-1-(1-methylethyl)-1H-imidazol-2-yl]-1H-1,2,4-- triazol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12- a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]p- yran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(4,5-dihydro-4,4-dimethyl-1H-imidazol-2-yl)-1H-1,2,4-triaz- ol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dod- ecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-- 7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(4,5-dihydro-1H-imidazol-- 2-yl)-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3-dimethyl-2-(methylamino)butyl]o- xy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahy- dro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-car- boxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-14-[5-(4,5-dihydro-1H-imidazol-2-yl)-1H-1,2,4-triazol-1-yl]-8- -[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1- ,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyl- ic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpro- pyl]-14-[5-(1,4,5,6-tetrahydro-2-pyrimidinyl)-1H-1,2,4-triazol-1-yl]-15-[[- (2R)-2,3,3-trimethyl-2-(methylamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,- 12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,- 2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-pyrrolidinyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4-a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[1,5'-bi-1H-1,2,4-triazol]-1'-yl-8-[(1R)-1,2-dimethylpropyl]-- 1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,- 4-a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(ethylthio)-1H-1,2,4-triazol-1- -yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-- 4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(ethylsulfonyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-phenyl-1H-1,2,4-triazol-1-yl)-- 1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,- 4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-phenyl-1H-1,2,4-triazol-1-y- l)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H- -1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- (5-phenyl-1H-1,2,4-triazol-1-yl)-15-[[tetrahydro-4-(methylamino)-2H-pyran-- 4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tet- ramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-furanyl)-1H-1,2,4-triazol-1- -yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-- 4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-ethenyl-1H-1,2,4-triazol-1-yl)- -1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1- ,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-ethyl-1H-1,2,4-triazol-1-yl)-1- ,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4- a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-piperidinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-morpholinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-piperidinyl)-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-phenyl-1H-1,2,4-triazo- l-1-yl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrameth- yl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-fluorophenyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-fluorophenyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-fluorophenyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dimeth- ylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(4-bromophenyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dimethy- lpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-methoxyphenyl)-1H-1,2,4-tri- azol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-methoxyphenyl)-1H-1,2,4-tri- azol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-naphthalenyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-naphthalenyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-thienyl)-1H-1,2,4-triazol-1- -yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-- 4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-thienyl)-1H-1,2,4-t- riazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetr- amethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-thienyl)-1H-1,2,4-triazol-1- -yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-- 4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-thienyl)-1H-1,2,4-t- riazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetr- amethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1H-pyrazol-4-yl)-1H-1- ,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-ethenyl-1H-1,2,4-triaz- ol-1-yl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(1E)-1-propenyl]-1H-1,2,4-tri- azol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(1Z)-1-propenyl]-1H-1,2,4-tri- azol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-methylethenyl)-1H-1,2,4-tri- azol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-propyl-1H-1,2,4-triazol-1-yl)-- 1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,- 4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[(E)-2-cyclopropylethenyl- ]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3-dimethyl-2-(methylamino)butyl]oxy]-- 8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-- dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(E)-2-phenylethenyl]- -1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a- ,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dim- ethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-phenylethenyl)-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3,3-trimethyl-2-(methy- lamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a- -tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(2-bromo-4-pyridinyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-d- imethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(5-pyrimidinyl)-1H-1,2,4-tr- iazol-1-yl]1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-14-[5-(4-cyanophenyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dime- thylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[4-(aminomethyl)phenyl]-1- H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-- 1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,1- 0a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[2-(ethoxycarbonyl)-4- -pyridinyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodec- ahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-- carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[2-(aminocarbonyl)-4-pyri- dinyl]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-- 8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpr- opyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methyl- amino)-2H-pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydr- o-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbo- xylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-pyridinyl)-1H-1,2,4-triazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-pyridinyl)-1H-1,2,4- -triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4- -triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-pyridinyl)-1H-1,2,4- -triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-pyrazinyl-1H-1,2,4-triazol-1-y- l)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H- -1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridazinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-pyridazinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyrimidinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(5-pyrimidinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-pyrimidinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(5-thiazolyl)-1H-1,2,4-triazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-thiazolyl)-1H-1,2,4-triazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-thiazolyl)-1H-1,2,4-triazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-methoxy-4-pyridinyl)-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(3-fluoro-4-pyridinyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-- dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-t- etramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-hydroxy-4-pyridinyl)-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(6-hydroxy-3-pyridinyl)-1H-1,2- ,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(4-aminophenyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dimethy- lpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-pyridinyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridazinyl)-1H-1,2,4-tr- iazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyrimidinyl)-1H-1,2,4-tr- iazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(5-thiazolyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-14-[5-(2-bromo-5-thiazolyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,- 2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a- -tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1H-imidazol-4-yl)-1H-1,2,4- -triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-methyl-1H-imidazol-4-yl)- -1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a- ,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-fluoro-4-pyridinyl- )-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6- a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-14-[5-(3-chloro-4-pyridinyl)-1H-1,2,4-triazol-1-yl]-8-[- (1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6- a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-14-[5-(3,5-difluoro-4-pyridinyl)-1H-1,2,4-triazol-1-yl]- -8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbox- ylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3- ,3-trimethylbutyl]oxy]-14-[5-(2-bromo-4-pyridinyl)-1H-1,2,4-triazol-1-yl]-- 8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,- 3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-methoxy-4-pyrid- inyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbox- ylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3- ,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-hydroxy-4-pyri- dinyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydr- o-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbo- xylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(2-amino-4-pyridinyl)-1H-- 1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,- 2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a- -tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[2-(formylamino)-4-pyridiny- l]-1H-1,2,4-triazol-1-yl]1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6- a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-methyl-4-pyridinyl- )-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6- a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2,6-dimethyl-4-pyrid- inyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbox- ylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3- ,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(6-hydroxy-3-pyri- dinyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydr- o-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbo- xylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[2-(methoxycarbonyl)-4-pyri- dinyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydr- o-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbo- xylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[6-(methoxycarbonyl)-3-pyri- dinyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydr- o-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbo- xylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[6-(aminocarbonyl)-3-pyri- dinyl]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-- 8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,- 3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[4-(methoxycarbony- l)-2-pyridinyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-d- odecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyra- n-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[4-(ethoxycarbonyl)-2-pyrid- inyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbox- ylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3- ,3-trimethylbutyl]oxy]-14-[5-(4-carboxy-2-pyridinyl)-1H-1,2,4-triazol-1-yl- ]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydr- o-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbo- xylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[4-(aminocarbonyl)-2-pyri- dinyl]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-- 8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[5-(aminocarbony- l)-2-pyridinyl]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbu- tyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dod- ecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-- 7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-14-[5-(3-cyanophenyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-dime- thylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[3-(aminocarbonyl)phenyl]- -1H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R- )-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8- ,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[3-(methoxycarbonyl)p- henyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydr- o-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbo- xylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[3-(aminomethyl)phenyl]-1- H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-- 1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,1- 0a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-14-[5-(3,4-difluorophenyl)-1H-1,2,4-triazol-1-yl]-8-[(1- R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-hydroxyphenyl)-1H-- 1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,1- 0a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-ethoxyphenyl)-1H-1- ,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[4-(trifluoromethyl)phenyl]- -1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a- ,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-14-[5-(4-carboxyphenyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-- 1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,1- 0a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[4-(methoxycarbonyl)p- henyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydr- o-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbo- xylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[4-(ethoxycarbonyl)phenyl]-- 1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[4-(aminocarbonyl)p- henyl]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-- 8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,- 3-trimethylbutyl]oxy]-14-[5-[4-[(dimethylamino)methyl]phenyl]-1H-1,2,4-tri- azol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-d- odecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyra- n-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-(2-amino-2-methylpropoxy)-8-- [(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-1,6,6- a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-pr- opano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-(2-amino-2-ethylbutoxy)-8-[(- 1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,- 7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-prop- ano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [2-ethyl-2-(methylamino)butoxy]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]- -1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1- ,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-3,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2S)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2-phenylpropy- l]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-- yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4- H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2-(1-methylcy- clopropyl)propyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1- ,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-(dimethylamino)-2,3- ,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-- 1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,1- 0a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropy- l]-15-[[(2R)-2-(ethylamino)-2,3,3-trimethylbutyl]oxy]-14-[5-(4-pyridinyl)-- 1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropy- l]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3,3-trimethyl-2-- (propylamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a- ,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropy- l]-14-[5-(3-fluoro-4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3,3-tri- methyl-2-(methylamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecah- ydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-ca- rboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2-cyclopropyl- propyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-fluoro-4-pyridinyl)-1H-1,- 2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a- -tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H-pyran- -4-yl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-tr- iazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(3-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methylamino)-2H- -pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,- 10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H- -pyran-4-yl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-fluoro-4-pyridin- yl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1- ,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyl- ic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpro- pyl]-14-[5-(3-fluoro-4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4- -(methylamino)-2H-pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-do- decahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran- -7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H-pyran- -4-yl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyrimidinyl)-1H-1,2,4-- triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tet- ramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H-pyran- -4-yl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(5-pyrimidinyl)-1H-1,2,4-- triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tet- ramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(4-pyrimidinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methylamino)-- 2H-pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropy- l]-14-[5-(5-pyrimidinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methyla- mino)-2H-pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbox- ylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3- ,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-oxido-4-pyridi- nyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,- 3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-oxido-3-pyridin- yl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1- ,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyl- ic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-d- imethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-oxido-4-pyridinyl)-- 1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-methyl-4-pyridiniu- myl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,- 3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-methyl-3-pyridi- niumyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahyd- ro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carb- oxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-methyl-4-pyridiniumyl)-1H-1- ,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-ethyl-4-pyridiniumyl)-1H- -1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,- 10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-[(aminocarbon- yl)amino]-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-p- yridinyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecah- ydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-ca- rboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-14-[5-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-1H-1,2,4-triaz- ol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dod- ecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-- 7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-14-[5-[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-1H-1,2,4-triaz- ol-1-yl]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dod- ecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-- 7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(5-[2,4'-bipyridin]-4-yl-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-d- imethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-phenyl-4-pyridinyl)-1H-1,2,- 4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-t- etramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(5-[2,3'-bipyridin]-4-yl-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-d- imethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(5-[2,2'-bipyridin]-4-yl-1H-1,2,4-triazol-1-yl)-8-[(1R)-1,2-d- imethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-piperidinyl)-1H-1,2,4-tr- iazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(1-acetyl-4-piperidinyl)-- 1H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)- -1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,- 10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[1-(methoxycarbonyl)-- 4-piperidinyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-do- decahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran- -7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-methyl-4-piperidinyl)-1H- -1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,- 10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(2S)-2-pyrrolidinyl]- -1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a- ,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(3R)-3-pyrrolidinyl]- -1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a- ,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(3S)-3-pyrrolidinyl]- -1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a- ,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-14-[5-(3-azetidinyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2- -dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-ethyl-3-azetidinyl)-1H-1- ,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[(3R)-1-(aminocarbonyl)-3- -pyrrolidinyl]-1H-1,2,4-triazol-1-yl]15-[[(2R)-2-amino-2,3,3-trimethylbuty- l]oxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodec- ahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-- carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[(3S)-1-(aminocarbonyl)-3- -pyrrolidinyl]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbut- yl]oxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dode- cahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7- -carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(tetrahydro-2H-pyran-4-yl)-- 1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-t- rimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[4-(methoxycarbonyl)c- yclohexyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodeca- hydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-c- arboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-[4-(aminocarbonyl)cyclohe- xyl]-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-- [(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,- 6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyli- c acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-di- methylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(1H-1,2,3-triazol-1-yl)-1,- 6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a- -propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(2H-1,2,3-triazol-2-yl)-1,6,6a,7,- 8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propan- o-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[4-(methoxycarbonyl)-1H-1,2,3-tri- azol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(methoxycarbonyl)-1H-1,2,3-tri- azol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[4-(methoxycarbonyl)-2H-1,2,3-tri- azol-2-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetram- ethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[4-amino-5-(aminocarbonyl)-2- H-1,2,3-triazol-2-yl]-15-[[(2R)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2- -dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-- tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(1H-pyrazol-1-yl)-1,6,6a,7,8,9,10- ,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-p- henanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[3-(aminocarbonyl)-1H-pyrazo- l-1-yl]-15-[[(2R)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropy- l]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H- -1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-pyrazo- l-1-yl]-15-[[(2R)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropy- l]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H- -1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(3-nitro-1H-pyrazol-1-yl)-1,6,6a,- 7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-prop- ano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-nitro-1H-pyrazol-1-yl)-1,6,6a,- 7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-prop- ano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-3,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(4-nitro-1H-pyrazol-1-yl)-1,6,6a,- 7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-prop- ano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-(4-chloro-1H-pyrazol-1-yl)-8-[(1R)-1,2-dimethylpropyl]-1,6,6a- ,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-pro- pano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(trifluoromethyl)-1H-pyrazol-1- -yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-- 4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(ethoxycarbonyl)-1H-pyrazol-1-- yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4- H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[(ethylamino)carbonyl]-1H-pyra- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-phenyl-1H-pyrazol-1-yl)-1,6,6a- ,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-pro- pano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[2-(ethoxycarbonyl)-1H-imidazol-1- -yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-- 4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[2-(aminocarbonyl)-1H-imidaz- ol-1-yl]-15-[[(2S)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylprop- yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4- H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2S)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxamide; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- (3-morpholinylmethoxy)-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7- ,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propa- no-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[1-(ethylamino)cyclobutyl]methoxy]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1- -yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-- 4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[(2S)-2-pyrrolidinylmethoxy]-1,- 6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a- -propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[(2R)-2-pyrrolidinylmethoxy]-1,- 6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a- -propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[(2R)-2-methyl-2-pyrrolidinyl]methoxy]-14-[5-(4-pyridinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-14-[5-(4-pyridinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [[(2R)-1-methyl-2-pyrrolidinyl]methoxy]-14-[5-(4-pyridinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-(5-imidazo[1,2-a]pyridin-- 7-yl-1H-1,2,4-triazol-1-yl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl- -2-(methylamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-methoxy-4-- pyridinyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodeca- hydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-c- arboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-pyraz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-methoxyphenyl)-1H-p- yrazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetr- amethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-thienyl)-1H-pyrazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-thiazolyl)-1H-pyraz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-pyridinyl)-1H-pyraz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-fluorophenyl)-1H-py- razol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[4-(trifluoromethyl)ph- enyl]-1H-pyrazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; and pharmaceutically acceptable salts thereof. 43. The compound according to claim 1, wherein the compound is selected from the group consisting of: (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3,3-trimethyl-2-(methy- lamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a- -tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(5-pyrimidinyl)-1H-1,2,4-tr- iazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methylamino)-2H- -pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,- 10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dim- ethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-pyridinyl)-1H-1,2,4-t- riazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetr- amethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-pyridinyl)-1H-1,2,4- -triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4- -triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyrimidinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(5-pyrimidinyl)-1H-1,2,4-triaz- ol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramet- hyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-14-[5-(3-fluoro-4-pyridinyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1,2-- dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-t- etramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-pyridinyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyrimidinyl)-1H-1,2,4-tr- iazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-fluoro-4-pyridinyl)-1H-1- ,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-14-[5-(3-chloro-4-pyridinyl)-1H-1,2,4-triazol-1-yl]-8-[(1R)-1- ,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-(2-amino-2-methylpropoxy)-8-- [(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-1,6,6- a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-pr- opano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-(2-amino-2-ethylbutoxy)-8-[(- 1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,- 7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-prop- ano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-15-- [2-ethyl-2-(methylamino)butoxy]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]- -1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1- ,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2-(1-methylcy- clopropyl)propyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1- ,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-(dimethylamino)-2,3- ,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-- 1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,1- 0a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropy- l]-15-[[(2R)-2-(ethylamino)-2,3,3-trimethylbutyl]oxy]-14-[5-(4-pyridinyl)-- 1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropy- l]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3,3-trimethyl-2-- (propylamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a- ,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropy- l]-14-[5-(3-fluoro-4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3,3-tri- methyl-2-(methylamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecah- ydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-ca- rboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2-cyclopropyl- propyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(2-fluorophenyl)-1H-1,2,4-tr- iazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H-pyran- -4-yl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-tr- iazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(3-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methylamino)-2H- -pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,- 10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H- -pyran-4-yl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-fluoro-4-pyridin- yl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1- ,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyl- ic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpro- pyl]-14-[5-(3-fluoro-4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4- -(methylamino)-2H-pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-do- decahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran- -7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H-pyran- -4-yl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(5-pyrimidinyl)-1H-1,2,4-- triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tet- ramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[(4-aminotetrahydro-2H-pyran- -4-yl)methoxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyrimidinyl)-1H-1,2,4-- triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tet- ramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(4-pyrimidinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methylamino)-- 2H-pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropy- l]-14-[5-(5-pyrimidinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methyla- mino)-2H-pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro- -1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carbox- ylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3- ,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-oxido-4-pyridi- nyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-- 1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxy- lic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,- 3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-oxido-3-pyridin- yl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1- ,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxyl- ic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-d- imethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(1-oxido-4-pyridinyl)-- 1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,- 8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; and pharmaceutically acceptable salts thereof. 44. The compound according to claim 1, wherein the compound is selected from the group consisting of: (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(1-methylethyl)amino- ]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodeca- hydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-c- arboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-[5-(aminocarbonyl)-1H-1,2,4-- triazol-1-yl]-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dime- thylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetra- methyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[(2R)-2,3,3-trimethyl-2-(methy- lamino)butyl]oxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a- -tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-8-[(1R)-1,2-dimethylpropyl]-14-- [5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-15-[[tetrahydro-4-(methylamino)-2H- -pyran-4-yl]methoxy]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,- 10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dim- ethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-pyridinyl)-1H-1,2,4-t- riazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetr- amethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3-dimethylb- utyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol- -1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethy- l-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methy- lamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4- -triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-te- tramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(3-fluoro-4-pyridinyl)-1H-1- ,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2-(1-methylcy- clopropyl)propyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1- ,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10- a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid; and pharmaceutically acceptable salts thereof. 45. A composition comprising the compound according to claim 1 and a pharmaceutically acceptable carrier, adjuvant or vehicle. 46. The composition according to claim 45, further comprising a second therapeutic agent. 47. A method of treating a fungal infection in a patient in need thereof, comprising administering to said patient an effective amount of the compound according to claim 1. 48. The method according to claim 47, wherein said fungal infection is caused by Cryptococcus spp., Candida spp. or Aspergillus spp. fungi. 49. The compound according to claim 1, wherein the compound is (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimeth- ylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-tria- zol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetrame- thyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid or a pharmaceutically acceptable salt thereof. 50. A composition comprising the compound according to claim 49 and a pharmaceutically acceptable carrier, adjuvant or vehicle. 51. A method of treating a fungal infection in a patient in need thereof, comprising administering to said patient an effective amount of the compound according to claim 49.