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Summary for Patent: 8,173,107
|Title:||Delivery of antipsychotics through an inhalation route|
|Abstract:||The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a method aspect of the present invention, an antipsychotic is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% antipsychotic drug degradation products. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route is provided which comprises: a) a thin coating of an antipsychotic composition and b) a device for dispensing said thin coating as a condensation aerosol.|
|Inventor(s):||Rabinowitz; Joshua D. (Princeton, NJ), Zaffaroni; Alejandro C. (Atherton, CA)|
|Assignee:||Alexza Pharmaceuticals, Inc. (Mountain View, CA)|
1. An aerosol for delivery of loxapine by inhalation comprising condensation particles having an MMAD of 0.2 to 5 microns and a high particle concentration of the
2. The aerosol of claim 1, wherein the aerosol is at least 90% free of additional compounds.
3. The aerosol of claim 1, wherein the condensation particles have and MMAD of 1-3 microns.
4. The aerosol of claim 1, wherein the high particle concentration of the condensation particles is about 10.sup.9 particles/ml.
5. An aerosol for delivery of loxapine by inhalation comprising condensation particles having an MMAD of 0.2 to 5 microns and a particle density greater than 10.sup.6 particles/ml.
6. The aerosol of claim 5, wherein the aerosol is at least 90% free of additional compounds.
7. The aerosol of claim 5, wherein the condensation particles have an MMAD of 1-3 microns.
8. The aerosol of claim 5, wherein the aerosol has a particle density of about 10.sup.9 particles/ml.
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