|Title:||Methods and compositions for treatment of ion imbalances|
|Abstract:||The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.|
|Inventor(s):||Charmot; Dominique (Campbell, CA), Liu; Mingjun (Campbell, CA)|
|Assignee:||Relypsa, Inc. (Santa Clara, CA)|
1. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a cation exchange, crosslinked alpha-fluoroacrylic acid polymer or a salt
thereof, wherein the alpha-fluoroacrylic acid polymer is crosslinked with divinylbenzene and is in bead form.
2. The pharmaceutical composition of claim 1 suitable for oral or intestinal administration.
3. The pharmaceutical composition of claim 2 suitable for oral administration.
4. The pharmaceutical composition of claim 2 suitable for intestinal administration.