Generated: April 28, 2017
|Title:||Methods and compositions for treatment of ion imbalances|
|Abstract:||The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.|
|Inventor(s):||Charmot; Dominique (Campbell, CA), Liu; Mingjun (Campbell, CA)|
|Assignee:||Relypsa, Inc. (Santa Clara, CA)|
1. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a cation exchange, crosslinked alpha-fluoroacrylic acid polymer or a salt
thereof, wherein the alpha-fluoroacrylic acid polymer is crosslinked with divinylbenzene and is in bead form.
2. The pharmaceutical composition of claim 1 suitable for oral or intestinal administration.
3. The pharmaceutical composition of claim 2 suitable for oral administration.
4. The pharmaceutical composition of claim 2 suitable for intestinal administration.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.