Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Federal Trade Commission
Fuji
Express Scripts
Cipla
Teva
Chubb
Deloitte
Daiichi Sankyo
Cantor Fitzgerald
Merck

Generated: August 23, 2017

DrugPatentWatch Database Preview

Claims for Patent: ► Subscribe

« Back to Dashboard

Claims for Patent: ► Subscribe

Title:.omega.-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
Inventor(s): Riedl; Bernd (Wuppertal, DE), Dumas; Jacques (Orange, CT), Khire; Uday (Hamden, CT), Lowinger; Timothy B. (Nishinomiya, JP), Scott; William J. (Guilford, CT), Smith; Roger A. (Madison, CT), Wood; Jill E. (North Haven, CT), Natero; Reina (Hamden, CT)
Assignee: Bayer Healthcare LLC (Tarrytown, NY)
Application Number:09/993,647
Patent Claims: 1. A method for the treatment of carcinoma of the lung, pancreas, thyroid, bladder or colon in a human or animal in need thereof comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-carbamoyl-4-pyridyloxy)ph- enyl)urea of the formula: ##STR00186## N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00187## or a pharmaceutically acceptable salt thereof.

2. A method for the treatment of myeloid leukemia in a human in need thereof comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-carbamoyl-4-pyridyloxy)ph- enyl)urea of the formula: ##STR00188## N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00189## or a pharmaceutically acceptable salt thereof.

3. A method of claim 1 for the treatment of carcinoma of the lung in a human in need thereof.

4. A method of claim 1 for the treatment of carcinoma of the pancreas in a human in need thereof.

5. A method of claim 1 for the treatment of carcinoma of the thyroid in a human in need thereof.

6. A method of claim 1 for the treatment of carcinoma of the bladder in a human in need thereof.

7. A method of claim 1 for the treatment of carcinoma of the colon in a human in need thereof.

8. A method for the treatment of carcinoma of the lung, pancreas, thyroid, bladder or colon in a human or animal in need thereof comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00190##

9. A method for the treatment of myeloid leukemia in a human in need thereof comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-- pyridyloxy)phenyl)urea of the formula: ##STR00191##

10. A method of claim 8 for the treatment of carcinoma of the lung in a human in need thereof.

11. A method of claim 8 for the treatment of carcinoma of the pancreas in a human in need thereof.

12. A method of claim 8 for the treatment of carcinoma of the thyroid in a human in need thereof.

13. A method of claim 8 for the treatment of carcinoma of the bladder in a human in need thereof.

14. A method of claim 8 for the treatment of carcinoma of the colon in a human in need thereof.

15. A method for the treatment of villous colon adenoma comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-carbamoyl-4-pyridyloxy)ph- enyl)urea of the formula: ##STR00192## N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00193## or a pharmaceutically acceptable salt thereof.

16. A method for the treatment of villous colon adenoma comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00194##
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Fish and Richardson
Cerilliant
Boehringer Ingelheim
Dow
Argus Health
US Department of Justice
Covington
Julphar
AstraZeneca
Accenture

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot