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Claims for Patent: 8,124,630

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Claims for Patent: 8,124,630

Title:.omega.-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
Inventor(s): Riedl; Bernd (Wuppertal, DE), Dumas; Jacques (Orange, CT), Khire; Uday (Hamden, CT), Lowinger; Timothy B. (Nishinomiya, JP), Scott; William J. (Guilford, CT), Smith; Roger A. (Madison, CT), Wood; Jill E. (North Haven, CT), Natero; Reina (Hamden, CT)
Assignee: Bayer Healthcare LLC (Tarrytown, NY)
Application Number:09/993,647
Patent Claims: 1. A method for the treatment of carcinoma of the lung, pancreas, thyroid, bladder or colon in a human or animal in need thereof comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-carbamoyl-4-pyridyloxy)ph- enyl)urea of the formula: ##STR00186## N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00187## or a pharmaceutically acceptable salt thereof.

2. A method for the treatment of myeloid leukemia in a human in need thereof comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-carbamoyl-4-pyridyloxy)ph- enyl)urea of the formula: ##STR00188## N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00189## or a pharmaceutically acceptable salt thereof.

3. A method of claim 1 for the treatment of carcinoma of the lung in a human in need thereof.

4. A method of claim 1 for the treatment of carcinoma of the pancreas in a human in need thereof.

5. A method of claim 1 for the treatment of carcinoma of the thyroid in a human in need thereof.

6. A method of claim 1 for the treatment of carcinoma of the bladder in a human in need thereof.

7. A method of claim 1 for the treatment of carcinoma of the colon in a human in need thereof.

8. A method for the treatment of carcinoma of the lung, pancreas, thyroid, bladder or colon in a human or animal in need thereof comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00190##

9. A method for the treatment of myeloid leukemia in a human in need thereof comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-- pyridyloxy)phenyl)urea of the formula: ##STR00191##

10. A method of claim 8 for the treatment of carcinoma of the lung in a human in need thereof.

11. A method of claim 8 for the treatment of carcinoma of the pancreas in a human in need thereof.

12. A method of claim 8 for the treatment of carcinoma of the thyroid in a human in need thereof.

13. A method of claim 8 for the treatment of carcinoma of the bladder in a human in need thereof.

14. A method of claim 8 for the treatment of carcinoma of the colon in a human in need thereof.

15. A method for the treatment of villous colon adenoma comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-carbamoyl-4-pyridyloxy)ph- enyl)urea of the formula: ##STR00192## N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00193## or a pharmaceutically acceptable salt thereof.

16. A method for the treatment of villous colon adenoma comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00194##
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